MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform

Abstract

Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed.

What is claimed is: 
     
         1 . A method for treating an ovarian cancer in a subject, the method comprising: administering to the subject in need thereof a therapeutically effective amount of an ovarian receptor agonist comprising: an inhibitor of one or more of: miR-21, miR-92, miR-93, miR-126, and miR-29a, or functional variants thereof. 
     
     
         2 . The method of  claim 1 , wherein the inhibitor comprises one or more of anti-miR-21, anti-miR-92, anti-miR-93, anti-miR-126, and anti-miR-29a. 
     
     
         3 . A method for treating an ovarian cancer in a subject, the method comprising:
 administering to the subject in need thereof a therapeutically effective amount of an ovarian receptor agonist comprising: an inducer of one or more of: miR-155, miR-127, and miR-99b, or functional variants thereof.   
     
     
         4 . Use of a nucleic acid molecule chosen from one or more of: miR-21, mi-R92, miR-93, miR-126, miR-29a, miR-155, miR-127, and miR-99b, or functional variants thereof among the miR, for the manufacture of a medicament for the treatment of an ovarian cancer. 
     
     
         5 . The use according to  claim 4 , wherein the drug comprises a nucleic acid molecule presenting a sequence chosen from one or more of: miR-21, miR-92, miR-93, miR-126, miR-29a, miR-155, miR-127, and miR-99b, or functional variants thereof among the miR.