Use of APC analogue for wound healing

Abstract

The present application relates to wound repair and wound healing by the application of a therapeutic amount of Activated Protein C-3K3A (‘APC-3K3A’). Specifically, this application is directed to a method of using APC-3K3A for the treatment of dermal or cutaneous wounds, including but not limited to, acute and chronic wounds, burns and ulcers.

1 . A method for the treatment of a dermal wound including the step of contacting a dermal wound with an effective amount of APC-3K3A, thereby treating the dermal wound. 
     
     
         2 . The method of  claim 1  including the step of topically administering the APC-3K3A to the wound, thereby contacting the dermal wound with the effective amount of APC-3K3A. 
     
     
         3 . The method of  claim 2  wherein APC-3K3A is topically administered to the wound in the form of a formulation selected from the group consisting of a gel, an ointment, a lotion and a spray. 
     
     
         4 . The method of  claim 1  wherein the APC-3K3A is administered to the wound by injection, thereby contacting the wound with an effective amount of APC-3K3A. 
     
     
         5 . The method of any one of the preceding claims wherein the dermal wound is not characterised by significant apoptosis, or otherwise does not arise from apoptosis. 
     
     
         6 . The method of any one of the preceding claims wherein the wound is a chronic or an acute wound. 
     
     
         7 . The method of any one of the preceding claims wherein the wound is a burn, incision, laceration, abrasion, puncture or ulcer. 
     
     
         8 . The method of any one of the preceding claims wherein the APC-3K3A is provided in an amount of 250 μg or 500 μg.