Pyrimidine compound and medical use thereof

Abstract

The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

1 .- 24 . (canceled) 
     
     
         25 . A method of preparing a compound of the formula: 
       
         
           
           
               
               
           
         
       
       comprising
 (a) reacting 
 
       
         
           
           
               
               
           
         
       
       with cyclopropylamine to form 
       
         
           
           
               
               
           
         
         (b) reacting the product of step (a) with 
       
       
         
           
           
               
               
           
         
       
       to form 
       
         
           
           
               
               
           
         
         (c) converting the product of step (b) to 
       
       
         
           
           
               
               
           
         
         (d) converting the product of step (c) to 
       
       
         
           
           
               
               
           
         
         (e) reacting the product of step (d) with 
       
       
         
           
           
               
               
           
         
       
       to form 
       
         
           
           
               
               
           
         
         (f) reacting the product of step (e) with 
       
       
         
           
           
               
               
           
         
       
       to form 
       
         
           
           
               
               
           
         
       
       and
 (g) reacting the product of step (f) with 
 
       
         
           
           
               
               
           
         
       
       to form 
       
         
           
           
               
               
           
         
       
     
     
         26 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a salt or solvate thereof. 
     
     
         27 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a salt or solvate thereof. 
     
     
         28 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a salt or solvate thereof. 
     
     
         29 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a salt or solvate thereof. 
     
     
         30 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a salt or solvate thereof. 
     
     
         31 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a salt or solvate thereof.