US2017028018A1PendingUtilityA1

Irisin for care and prevention of osteoporosis

Assignee: UNIVERSITA' DEGLI STUDI DI BARIPriority: Apr 16, 2015Filed: Apr 14, 2016Published: Feb 2, 2017
Est. expiryApr 16, 2035(~8.7 yrs left)· nominal 20-yr term from priority
A61P 19/00A61P 19/10A61K 38/17A61K 38/22
21
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Claims

Abstract

Object of the present invention is the use of Irisin for the treatment and/or prevention of osteoporosis. In particular, the present invention refers to the use of recombinant irisin for the treatment and/or prevention of osteoporosis.

Claims

exact text as granted — not AI-modified
1 . Irisin for use in the treatment and/or prevention of osteoporosis. 
     
     
         2 . The irisin for use according to  claim 1 , wherein said irisin is recombinant irisin. 
     
     
         3 . The irisin for use according to  claim 2 , wherein said recombinant irisin comprises the amino acid sequence: 
       
         
           
                 
               
                   (SEQ. ID NO. 1) 
                 
                        DSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRM 
                 
                     
                 
                   LRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPR 
                 
                     
                 
                   EAEKMASKNKDEVTMKE. 
                 
             
                
                
                
                
                
                
               
            
           
         
       
     
     
         4 . The irisin for use according to  claim 1 , wherein a dosage of said irisin is between 500 μg/kg and 50 μg/kg. 
     
     
         5 . The irisin for use according to  claim 1 , wherein a dosage of said irisin is between 250 μg/kg and 75 μg/kg. 
     
     
         6 . The irisin for use according to  claim 1 , wherein a dosage of said irisin is 100 μg/kg. 
     
     
         7 . Compositions comprising irisin for use in the treatment and/or prevention of osteoporosis. 
     
     
         8 . The compositions for use according to  claim 7 , wherein said irisin is recombinant irisin. 
     
     
         9 . The compositions for use according to  claim 8 , wherein said recombinant irisin comprises the amino acid sequence: 
       
         
           
                 
               
                   (SEQ. ID NO. 1) 
                 
                        DSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRM 
                 
                     
                 
                   LRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPR 
                 
                     
                 
                   EAEKMASKNKDEVTMKE. 
                 
             
                
                
                
                
                
                
               
            
           
         
       
     
     
         10 . The compositions for use according to  claim 7 , wherein said irisin comprises excipients and/or additives for pharmaceutical use.

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