Intrinsic frequency hemodynamic waveform analysis

Abstract

Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/ measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition.

1 . A system for acquiring and analyzing a hemodynamic waveform of a subject, the system comprising:
 an optical scanner, the scanner adapted to capture a signal corresponding to a hemodynamic waveform; and   at least one computer processor connected to the scanner by a wired or wireless connection, wherein the computer processor is adapted to receive the signal for the hemodynamic waveform, determine a Dicrotic Notch using the signal, calculate first and second intrinsic frequencies (ω 1 , ω 2 ) on each side of the Dicrotic Notch for the waveform, and output a signal corresponding to intrinsic frequencies results.   
     
     
         2 . A computer-implemented method of analyzing a signal, comprising:
 inputting a hemodynamic waveform data for a subject, the waveform including a Dicrotic Notch;   determining a position of the Dicrotic Notch in the waveform for dividing the signal into first and second sections for analysis;   analyzing each of the first and second sections of the waves by to determine first and second intrinsic frequencies (ω 1 , ω 2 ) where each intrinsic frequency is at or about a frequency that carries the highest energy for all frequencies of an instantaneous frequency curve; and   outputting a result of the analyzing.