Method of treating or inhibiting the development of brain inflammation and sepsis

Abstract

A leukotriene C4 and D4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after administration of an inflammation inducing agent into the subarachnoid space by determining their ability to inhibit increased capillary permeability and white blood cell extravasation.

1 .- 6 . (canceled) 
     
     
         7 . An inhibitor of increased capillary permeability of blood brain barrier for a mammal, comprising pranlukast as an active ingredient, the inhibitor being administered at a dose such that a therapeutically effective amount of pranlukast ranges from 200 mg/day to 2000 mg/day. 
     
     
         8 . The inhibitor of increased capillary permeability of blood brain barrier according to claim  1 , wherein the mammal is human.