Compounds for the treatment of cancer

Abstract

The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI) wherein A and B are as defined herein, or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer.

1 . A FoxM1 gene splicing modifier selected from a compound of formula (I) or a compound of formula (VI) 
       
         
           
           
               
               
           
         
         wherein 
         A is 2-hydroxy-phenyl which is substituted with:
 0, 1, 2, or 3 substituents independently selected from C 1-4  alkyl, oxo, oxime, hydroxy, halo-C 1-4  alkyl, dihalo-C 1-4  alkyl, trihalo-C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkoxy-C 3-7  cycloalkyl, halo-C 1-4  alkoxy, dihalo-C 1-4  alkoxy, trihalo-C 1-4  alkoxy, hydroxy, cyano, halogen, amino, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, heteroaryl, C 1-4  alkyl substituted with hydroxy, C 1-4  alkoxy substituted with aryl, amino, —C(O)NH—C 1-4 alkyl-heteroaryl, —NHC(O)—C 1-4  alkylheteroaryl, C 1-4  alkyl-C(O)NH-heteroaryl, C 1-4 alkyl-NHC(O)-heteroaryl, C 3-7  cycloalkyl, 5-7 membered cycloalkenyl, or 5, 6 or 9 membered heterocycle containing 1 or 2 heteroatoms independently, selected from S, O and N, 
 wherein two C 1-4  alkyl groups can combine with the atoms to which they are bound to form a 5-6 membered ring; 
 wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S, and is substituted with 0, 1, or 2 substituents independently selected from oxo, hydroxy, nitro, halogen, C 1-4  alkyl, C 1-4  alkenyl, C 1-4  alkoxy, C 3-7  cycloalkyl, C 1-4  alkyl-OH, trihalo-C 1-4  alkyl, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, —C(O)NH 2 , —NH 2 , NO 2 , hydroxy-C 1-4 alkylamino, hydroxy-C 1-4  alkyl, 4-7 membered heterocycle-C 1-4  alkyl, amino-C 1-4  alkyl, mono-C 1-4 alkylamino-C 1-4  alkyl, and di-C 1-4 alkylamino-C 1-4  alkyl; or 
 
         A is 2-naphthyl optionally substituted at the 3 position with hydroxy and additionally substituted with 0, 1, or 2 substituents selected from hydroxy, cyano, halogen, C 1-4  alkyl, C 2-4  alkenyl, C 1-5  alkoxy, wherein the alkoxy is unsubstituted or substituted with hydroxy, C 1-4  alkoxy, amino, —NHC(O)—C 1-4  alkyl, —NHC(O)O—C 1-4  alkyl, C 1-4  alkylene-4-7 membered heterocycle, 4-7 membered heterocycle, mono-C 1-4  alkylamino, and di-C 1-4  alkylamino; or 
         A is 6 membered heteroaryl having 1-3 ring nitrogen atoms and which is substituted by phenyl or a heteroaryl having 5 or 6 ring atoms, 1 or 2 ring heteroatoms independently selected from N, O and S and is substituted with 0, 1, or 2 substituents independently selected from C 1-4  alkyl, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, hydroxy-C 1-4  alkylamino, hydroxy-C 1-4  alkyl, amino-C 1-4  alkyl and mono-C 1-4  alkylamino-C 1-4  alkyl, and di-C 1-4 alkylamino-C 1-4  alkyl; or 
         A is bicyclic heteroaryl having 9 to 10 ring atoms, 1, 2, or 3 ring heteroatoms independently selected from N, O or S, and which is substituted with 0, 1, or 2 substituents independently selected from cyano, oxime, halogen, hydroxy, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 1-4  alkoxy substituted with hydroxy, amino, mono-C 1-4  alkylamino, and di-C 1-4  alkylamino; or 
         A is tricyclic heteroaryl having 12 or 13 ring atoms, 1, 2, or 3 ring heteroatoms independently selected from N, O or S, and which is substituted with 0, 1, or 2 substituents independently selected from cyano, halogen, hydroxy, C 1-4  alkyl, C 1-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 1-4  alkoxy substituted with hydroxy, amino, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, and heteroaryl having 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S, and which is substituted with 0, 1, or 2 substituents independently selected from oxo, hydroxy, nitro, halogen, C 1-4  alkyl, C 1-4  alkenyl, C 1-4  alkoxy, C 3-7  cycloalkyl, C 1-4  alkyl-OH, trihalo-C 1-4  alkyl, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, —C(O)NH 2 , —NH 2 , —NO 2 , hydroxy-C 1-4  alkylamino, hydroxy-C 1-4  alkyl, 4-7 membered heterocycle-C 1-4  alkyl, amino-C 1-4  alkyl, mono-C 1-4  alkylamino-C 1-4  alkyl and di-C 1-4  alkylamino-C 1-4  alkyl; or 
         A is phenyl which is substituted with 0, 1, 2, or 3 substituents independently selected from C 1-4  alkyl, oxo, oxime, hydroxy, halo-C 1-4  alkyl, dihalo-C 1-4  alkyl, trihalo-C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkoxy-C 3-7  cycloalkyl, halo-C 1-4  alkoxy, dihalo-C 1-4  alkoxy, trihalo-C 1-4  alkoxy, cyano, halogen, amino, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, heteroaryl, C 1-4  alkyl substituted with hydroxy, C 1-4  alkoxy substituted with aryl, —C(O)NH—C 1-4  alkyl-heteroaryl, —NHC(O)—C 1-4  alkylheteroaryl, C 1-4  alkyl-C(O)NH-heteroaryl, C 1-4  alkyl-NHC(O)-heteroaryl, C 3-7  cycloalkyl, 5-7 membered cycloalkenyl or 5, 6 or 9 membered heterocycle containing 1 or 2 heteroatoms, independently, selected from S, O and N;
 wherein two C 1-4  alkyl groups can combine with the atoms to which they are bound to form a 5-6 membered ring; 
 wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S and is substituted with 0, 1, or 2 substituents independently selected from oxo, hydroxy, nitro, halogen, C 1-4  alkyl, C 1-4  alkenyl, C 1-4  alkoxy, C 3-7  cycloalkyl, C 1-4  alkyl-OH, trihalo-C 1-4  alkyl, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, —C(O)NH 2 , —NH 2 ,—NO 2 , hydroxy-C 1-4  alkylamino, hydroxy-C 1-4  alkyl, 4-7 memberered heterocycle-C 1-4  alkyl, amino-C 1-4  alkyl, mono-C 1-4  alkylamino-C 1-4  alkyl, and di-C 1-4  alkylamino-C 1-4  alkyl; 
 
         B is a group of the formula 
       
       
         
           
           
               
               
           
         
         wherein
 m, n and p are independently selected from 0 or 1; 
 R, R 1 , R 2 , R 3 , and R 4  are independently selected from the group consisting of hydrogen and C 1-4  alkyl, wherein alkyl is optionally substituted with hydroxy, amino, mono-C 1-4  akylamino or di-C 1-4  akylamino; 
 R 5  and R 6  are independently selected from hydrogen and fluorine; or 
 R and R 3 , taken in combination form a fused 5 or 6 membered heterocyclic ring having 0 or 1 additional ring heteroatoms selected from N, O or S; or 
 R 1  and R 3 , taken in combination form a C 1-3  alkylene group; or 
 R 1  and R 5 , taken in combination form a C 1-3  alkylene group; or 
 R 3  and R 4 , taken in combination with the carbon atom to which they attach, form a spirocyclic C 3-6  cycloalkyl; 
 X is CR A R B , O, NR 7  or a bond; 
 R 7  is hydrogen, or C 1-4  alkyl; 
 R A  and R B  are independently selected from hydrogen and C 1-4  alkyl, or R A  and R B , taken in combination, form a divalent C 2-5  alkylene group; 
 Z is CR 8  or N; with the proviso that when Z is N, X is a bond; 
 R 8  is hydrogen or taken in combination with R 6  form a double bond; or 
 
         B is a group of the formula 
       
       
         
           
           
               
               
           
         
         wherein
 p and q are independently selected from the group consisting of 0, 1, and 2; 
 R 9  and R 13  are independently selected from hydrogen and C 1-4  alkyl; 
 R 10  and R 14  are independently selected from hydrogen, amino, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, and C 1-4  alkyl optionally substituted with hydroxy, amino, mono-C 1-4  alkylamino or di-C 1-4  alkylamino; 
 R 11  is hydrogen, C 1-4  alkyl, amino, mono-C 1-4  alkylamino, or di-C 1-4  alkylamino; 
 R 12  is hydrogen or C 1-4  alkyl; or 
 R 9  and R 11  taken in combination form a saturated azacycle having 4 to 7 ring atoms which is optionally substituted with one to three C 1-4  alkyl groups; or 
 R 11  and R 12 , taken in combination form a saturated azacycle having 4 to 7 ring atoms which is optionally substituted with one to three C 1-4  alkyl groups. 
 
         or a pharmaceutically acceptable salt thereof; 
         for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         2 . The FoxM1 gene splicing modifier according to  claim 1 , wherein
 A is 2-hydroxy-phenyl which is substituted with:
 0, 1, 2, or 3 substituents independently selected from C 1-4  alkyl, oxo, oxime, hydroxy, halo-C 1-4  alkyl, dihalo-C 1-4  alkyl, trihalo-C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkoxy-C 3-7  cycloalkyl, halo-C 1-4  alkoxy, dihalo-C 1-4  alkoxy, trihalo-C 1-4  alkoxy, hydroxy, cyano, halogen, amino, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, heteroaryl, C 1-4  alkyl substituted with hydroxy, C 1-4  alkoxy substituted with aryl, amino, —C(O)NH—C 1-4 alkyl-heteroaryl, 
 —NHC(O)—C 1-4  alkylheteroaryl, C 1-4  alkyl-C(O)NH-heteroaryl, C 1-4 alkyl-NHC(O)-heteroaryl, C 3-7  cycloalkyl, 5-7 membered cycloalkenyl, or 5, 6 or 9 membered heterocycle containing 1 or 2 heteroatoms independently, selected from S, O and N, 
 wherein two C 1-4  alkyl groups can combine with the atoms to which they are bound to form a 5-6 membered ring; 
 wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S, and is substituted with 0, 1, or 2 substituents independently selected from oxo, hydroxy, nitro, halogen, C 1-4  alkyl, C 1-4  alkenyl, C 1-4  alkoxy, C 3-7  cycloalkyl, C 1-4  alkyl-OH, trihalo-C 1-4  alkyl, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, —C(O)NH 2 , —NH 2 , NO 2 , hydroxy-C 1-4 alkylamino, hydroxy-C 1-4  alkyl, 4-7 membered heterocycle-C 1-4  alkyl, amino-C 1-4  alkyl, mono-C 1-4 alkylamino-C 1-4  alkyl, and di-C 1-4 alkylamino-C 1-4  alkyl; or 
   A is 2-naphthyl optionally substituted at the 3 position with hydroxy and additionally substituted with 0, 1, or 2 substituents selected from hydroxy, cyano, halogen, C 1-4  alkyl, C 2-4  alkenyl, C 1-5  alkoxy, wherein the alkoxy is unsubstituted or substituted with hydroxy, C 1-4  alkoxy, amino, —NHC(O)—C 1-4  alkyl, —NHC(O)O—C 1-4  alkyl, C 1-4  alkylene-4-7 membered heterocycle, 4-7 membered heterocycle, mono-C 1-4  alkylamino, and di-C 1-4  alkylamino; or   A is phenyl which is substituted with 0, 1, 2, or 3 substituents independently selected from C 1-4  alkyl, oxo, oxime, hydroxy, halo-C 1-4  alkyl, dihalo-C 1-4  alkyl, trihalo-C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkoxy-C 3-7  cycloalkyl, halo-C 1-4  alkoxy, dihalo-C 1-4  alkoxy, trihalo-C 1-4  alkoxy, cyano, halogen, amino, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, heteroaryl, C 1-4  alkyl substituted with hydroxy, C 1-4  alkoxy substituted with aryl, —C(O)NH—C 1-4  alkyl-heteroaryl, —NHC(O)—C 1-4  alkylheteroaryl, C 1-4  alkyl-C(O)NH-heteroaryl, C 1-4  alkyl-NHC(O)-heteroaryl, C 3-7  cycloalkyl, 5-7 membered cycloalkenyl or 5, 6 or 9 membered heterocycle containing 1 or 2 heteroatoms, independently, selected from S, O and N;
 wherein two C 1-4  alkyl groups can combine with the atoms to which they are bound to form a 5-6 membered ring; 
 wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S and is substituted with 0, 1, or 2 substituents independently selected from oxo, hydroxy, nitro, halogen, C 1-4  alkyl, C 1-4  alkenyl, C 1-4  alkoxy, C 3-7  cycloalkyl, C 1-4  alkyl-OH, trihalo-C 1-4  alkyl, mono-C 1-4  alkylamino, di-C 1-4  alkylamino, —C(O)NH 2 , —NH 2 ,—NO 2 , hydroxy-C 1-4  alkylamino, hydroxy-C 1-4  alkyl, 4-7 memberered heterocycle-C 1-4  alkyl, amino-C 1-4  alkyl, mono-C 1-4  alkylamino-C 1-4  alkyl, and di-C 1-4  alkylamino-C 1-4  alkyl; 
   or a pharmaceutically acceptable salt thereof;
 for use in the treatment, prevention and/or delay of progression of cancer. 
   
     
     
         3 . The FoxM1 gene splicing modifier according to  claim 1 , wherein
 A is 2-hydroxy-phenyl substituted with one additional substituent selected from cyano and heteroaryl; or   A is 2-naphthyl optionally substituted at the 3 position with hydroxy and additionally substituted with 0 or 1 substituents selected from hydroxy and C 1-4  alkoxy; or   A is phenyl which is substituted with two or three substituents independently selected from halogen and heteroaryl;   wherein heteroaryl has 5 or 6 ring atoms of which 1 or 2 are nitrogen and is substituted with 0, 1, or 2 substituents independently selected from C 1-4  alkyl and hydroxy;   or a pharmaceutically acceptable salt thereof;   for use in the treatment, prevention and/or delay of progression of cancer.   
     
     
         4 . The FoxM1 gene splicing modifier according to  claim 1 , wherein A is selected from 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         wherein u and v are each, independently, 0, 1, 2 or 3; and each R a  and R b  are, independently, selected from cyano, halogen, hydroxy, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 3-7  cycloalkyl, heterocyclyl, heteroaryl, heterocyclyl-C 1-4  alkyl, C 1-4  alkyl-aryl, C 1-4  alkyl-heterocyclyl, C 1-4  alkyl-heteroaryl, C 1-4  alkoxy-aryl, C 1-4  alkoxy-heterocyclyl, C 1-4  alkoxy-heteroaryl, and C 1-4  alkoxy substituted with hydroxy, C 1-4  alkoxy, amino, mono-C 1-4  alkylamino and di-C 1-4  alkylamino; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         5 . The FoxM1 gene splicing modifier according to  claim 1 , wherein A is selected from 
       
         
           
           
               
               
           
         
         wherein u and v are each, independently, 0, 1, 2 or 3; and each R a  and R b  are, independently, selected from cyano, halogen, hydroxy, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 3-7  cycloalkyl, heterocyclyl, heteroaryl, heterocyclyl-C 1-4  alkyl, C 1-4  alkyl-aryl, C 1-4  alkyl-heterocyclyl, C 1-4  alkyl-heteroaryl, C 1-4  alkoxy-aryl, C 1-4  alkoxy-heterocyclyl, C 1-4  alkoxy-heteroaryl, C 1-4  alkoxy substituted with hydroxy, C 1-4  alkoxy, amino, mono-C 1-4  alkylamino and di-C 1-4  alkylamino; or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         6 . The FoxM1 gene splicing modifier according to  claim 1 , wherein A is substituted by one or more substituents as described in  claim 1 , wherein one of the substituents of A is hydroxy in ortho-positon to the pyridazine of formula (I) or to the thiadiazole of formula (VI); or a pharmaceutically acceptable salt thereof, for use in the treatment, prevention and/or delay of progression of cancer. 
     
     
         7 . The FoxM1 gene splicing modifier according to  claim 1  selected from a compound of formula (II): 
       
         
           
           
               
               
           
         
         wherein B is as defined in  claim 1  and R 15  is hydrogen, hydroxy, or C 1-4  alkoxy, wherein alkoxy is optionally substituted with hydroxy, methoxy, amino, mono-methylamino, di-methylamino or morpholine; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         8 . The FoxM1 gene splicing modifier according to  claim 1  selected from a compound of formula (III): 
       
         
           
           
               
               
           
         
         wherein B is as defined in  claim 1  and R 16  is cyano, 5-membered heteroaryl having two ring nitrogen atoms, or 6-membered heteroaryl having one ring nitrogen atom; wherein the 5-membered heteroaryl is optionally substituted with C 1-4  alkyl; wherein the 6-membered heteroaryl is optionally substituted with one or two substituents selected from C 1-4  alkyl and hydroxy; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         9 . The FoxM1 gene splicing modifier according to  claim 1  selected from a compound of formula (VII): 
       
         
           
           
               
               
           
         
         wherein B is as defined in  claim 1  and R 18  is 5-membered heteroaryl having two ring nitrogen atoms or 6-membered heteroaryl having one ring nitrogen atom; wherein the 5-membered heteroaryl is optionally substituted with C 1-4  alkyl; wherein the 6-membered heteroaryl is optionally substituted with one or two substituents selected from C 1-4  alkyl and hydroxy; R 19  is hydrogen or halogen; and R 20  is hydrogen or halogen; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         10 . The FoxM1 gene splicing modifier according to  claim 1 , wherein B is selected from the group consisting of 
       
         
           
           
               
               
           
         
         wherein X is O or —N(CH 3 )—; and R 17  is hydrogen or methyl; 
         or a pharmaceutically acceptable salt thereof; 
         for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         11 . The FoxM1 gene splicing modifier according to  claim 1 , wherein B is 
       
         
           
           
               
               
           
         
         and X is O or —N(CH 3 )—; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         12 . The FoxM1 gene splicing modifier according to  claim 1 , wherein X is O; or a pharmaceutically acceptable salt thereof;
 for use in the treatment, prevention and/or delay of progression of cancer.   
     
     
         13 . The FoxM1 gene splicing modifier according to  claim 1 , wherein X is —N(CH 3 )—; or a pharmaceutically acceptable salt thereof,
 for use in the treatment, prevention and/or delay of progression of cancer. 
 
     
     
         14 . The FoxM1 gene splicing modifier according to  claim 1 , wherein B is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof; 
         for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         15 . A FoxM1 gene splicing modifier selected from a compound of formula (IV) or of formula (V) or of formula (VIII): 
       
         
           
           
               
               
           
         
         wherein X is —O— or —N(CH 3 )—; R′ is cyano, pyrazolyl optionally substituted with methyl, or pyridinyl substituted with methyl and hydroxy; R″ is hydrogen, methyl or methoxy; R′″ is pyrazolyl optionally substituted with methyl, or pyridinyl substituted with methyl and hydroxy; R u  is hydrogen, chloro or fluoro; R v  is hydrogen, chloro or fluoro; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         16 . A FoxM1 gene splicing modifier selected from a compound of formula (IX) or of formula (X) or of formula (XI) or of formula (XII) or of formula (XIII) or of formula (XIV) or of formula (XV): 
       
         
           
           
               
               
           
         
         wherein X is —O— or —N(CH 3 )—; and each R C  and R d  are, independently, selected from hydrogen, cyano, halogen, hydroxy, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 3-7  cycloalkyl, heterocyclyl, heteroaryl, heterocyclyl-C 1-4  alkyl, C 1-4  alkyl-aryl, C 1-4  alkyl-heterocyclyl, C 1-4  alkyl-heteroaryl, C 1-4  alkoxy-aryl, C 1-4  alkoxy-heterocyclyl, C 1-4  alkoxy-heteroaryl, C 1-4  alkoxy substituted with hydroxy, C 1-4  alkoxy, amino, mono-C 1-4  alkylamino and di-C 1-4  alkylamino; or a pharmaceutically acceptable salt thereof; for use in the treatment, prevention and/or delay of progression of cancer. 
       
     
     
         17 . A FoxM1 gene splicing modifier according to  claim 1  selected from the group consisting of:
 6-(naphthalen-2-yl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 6-(benzo[b]thio-phen-2-yl)-N-methyl-N-(2,2,6,6-tetra-methylpiperidin-4-yl)pyridazin-3-amine; 
 2-(6-(2,2,6,6-tetra methylpiperidin-4-ylamino)-pyridazin-3-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetra-methylpiperidin-4-yl)amino)pyridazin-3-yl)benzo[b]-thiophene-5-carbonitrile; 
 6-(quinolin-3-yl)-N-(2,2,6,6-tetramethyl-piperidin-4-yl)pyridazin-3-amine; 
 3-(benzo[b]-thiophen-2-yl)-6-(2,2,6,6-tetra-methylpiperidin-4-yloxy)pyridazine; 
 2-(6-(methyl-(2,2,6,6-tetra-methylpiperidin-4-yl)amino)-pyridazin-3-yl)phenol; 
 6-(6-(methyl-(2,2,6,6-tetra-methylpiperidin-4-yl)amino)-pyridazin-3-yl)naphthalen-2-ol; 
 6-(benzo[b]-thiophen-2-yl)-N-(2,2,6,6-tetra-methylpiperidin-4-yl)pyridazin-3-amine; 
 7-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)isoquinoline; 
 6-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)isoquinoline; 
 N-methyl-6-(quinolin-7-yl)-N-(2,2,6,6-tetramethyl-piperidin-4-yl)pyridazin-3-amine; 
 N-methyl-6-(quinolin-6-yl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 6-(isoquinolin-7-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 6-(isoquinolin-6-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 6-(imidazo[1,2-a]pyridin-6-yl-pyridazin-3-yl)-methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine 
 methyl-[6-(6-phenyl-pyri din-3-yl)-pyridazin-3-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine; 
 methyl-[6-(6-pyrrol-1-yl-pyridin-3-yl)-pyridazin-3-yl]-(2,2,6,6-tetra methyl-piperidin-4-yl)-amine; 
 methyl-(6-quinoxalin-2-yl-pyridazin-3-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine; 
 methyl-(6-quinolin-3-yl-pyridazin-3-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine; 
 N-methyl-6-(phthalazin-6-yl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 6-(benzo[c][1,2,5]oxa-diazol-5-yl)-N-(2,2,6,6-tetramethyl-piperidin-4-yl)pyridazin-3-amine; 
 6-(benzo[d]thiazol-5-yl)-N-(2,2,6,6-tetramethyl-piperidin-4-yl)pyridazin-3-amine; 
 6-(2-methylbenzo-[d]oxazol-6-yl)-N-(2,2,6,6-tetramethyl-piperidin-4-yl)pyridazin-3-amine; 
 3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 5-chloro-2-(6-(methyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 3-(6-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyridazin-3-yl)naphthalen-2-ol; 
 5-chloro-2-(6-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)pyridazin-3-yl)phenol; 
 4-hydroxy-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)benzonitrile; 
 3-[6-(2,2,6,6-tetramethyl-piperidin-4-yloxy)-pyridazin-3-yl]-naphthalen-2-ol; 
 2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-4-trifluoromethylphenol; 
 2-fluoro-6-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 3,5-dimethoxy-2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 4,5-dimethoxy-2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 5-methoxy-2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 4,5-difluoro-2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 5-fluoro-2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 3-hydroxy-4-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)benzonitrile; 
 1-allyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 6-(benzo[b]thiophen-2-yl)-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyridazin-3-amine; 
 N-allyl-3-hydroxy-4-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)benzamide; 
 2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 5-(5-methyl-oxazol-2-yl)-2-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 5-(4-hydroxymethyl)-1H-pyrazole-1-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4 yl)amino)pyridazin-3-yl)phenol; 
 5-(1H-imidazole-1-yl)-2-(6-(methyl(2,2,6,6-tetramethyl-piperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(4-amino-1H-pyrazole-1-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(4-amino-1H-pyrazol-1-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(3-amino-pyrazol-1-yl)-2-{6-[methyl-(2,2,6,6-tetra methyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol; 
 5-(5-amino-1H-pyrazol-1-yl)-2-(6-(methyl-(2,2,6,6-tetramethyl-piperidin-4-yl) amino)pyridazin-3-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(1H-pyrazol-1-yl)phenol; 
 2-{6-[(2-hydroxy-ethyl)-(2,2,6,6-tetra methyl-piperidn-4-yl)-amino]-pyridazin-3-yl}-5-pyrazol-1-yl-phenol; 
 2-(6-(piperidin-4-yloxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 2-(6-(((2S,4R,6R)-2,6-dimethylpiperidin-4-yl)oxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 5 2-(6-((2,6-di-methylpiperidin-4-yl)oxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 2-(6-((2,6-di-methylpiperidin-4-yl)oxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 5-(1H-pyrazol-1-yl)-2-(6-(pyrrolidin-3-yloxy)pyridazin-3-yl)phenol; 
 2-(6-((-2-methylpiperidin-4-yl)oxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 (S)-5-(1H-pyrazol-1-yl)-2-(6-(pyrrolidin-3-ylmethoxy)pyridazin-3-yl)phenol; 
 (R)-5-(1H-pyrazol-1-yl)-2-(6-(pyrrolidin-3-yl methoxy)pyridazin-3-yl)phenol; 
 2-(6-((3-fluoropiperidin-4-yl)oxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)-phenol; 
 2-[6-(1,2,2,6,6-pentamethyl-piperidin-4-yloxy)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 5-pyrazol-1-yl-2-[6-((2,2,6,6-tetramethylpiperidin-4-yloxy)-pyridazin-3-yl]-phenol; 
 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol; 
 2-(6-piperazin-1-yl-pyridazin-3-yl)-5-pyrazol-1-yl-phenol; 
 3-[6-(azetidin-3-yl-amino)-pyridazin-3-yl]-naphthalen-2-ol; 
 2-[6-(azetidin-3-yl amino)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(3, 5-di methyl-piperazin-1-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(7-methyl-2,7-diaza-spiro[4.4]non-2-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-(6-[1,4]diazepan-1-yl-pyridazin-3-yl)-5-pyrazol-1-yl-phenol; 
 2-{6-[4-(2-hydroxy-ethyl)-piperazin-3-yl]-pyridazin-3-yl}-5-pyrazol-1-yl-phenol; 
 2-[6-(3, 6-diaza-bicyclo[3.2.1]oct-3-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(2, 7-diaza-spiro[3.5]non-7-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(3-hydroxy-methyl-piperazin-1-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(1, 7-diaza-spiro[4.4]non-7-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(4-amino-4-methyl-piperidin-1-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(3-dimethyl-amino-piperidin-1-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-[6-(3, 3-di methyl-piperazin-1-yl)-pyridazin-3-yl]-5-pyrazol-1-yl-phenol; 
 2-(6-(7-(2-hydroxyethyl)-2,7-diazaspiro[4.4]-nonan-2-yl)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 2-(6-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 3-(6-(piperazin-1-yl)pyridazin-3-yl)naphthalene-2,7-diol; 
 5-pyrazol-1-yl-2-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-pyridazin-3-yl]-phenol; 
 2-(6-piperidin-4-yl-pyridazin-3-yl)-5-pyrazol-1-yl-phenol; 
 3-(6-(1,2,3,6-tetra-hydropyridin-4-yl)pyridazin-3-yl)naphthalen-2-ol; 
 3-(6-(1,2,3,6-tetrahydropyridin-4-yl)pyridazin-3-yl)naphthalene-2,7-diol; 
 3-(6-(2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)pyridazin-3-yl)naphthalene-2,7-diol; 
 3-(6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyridazin-3-yl)naphthalene-2,7-diol; 
 3-(6-(piperidin-4-yl)pyridazin-3-yl)naphthalene-2,7-diol; 
 3-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)naphthalene-2,7-diol; 
 3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalene-2,7-diol; 
 3-(6-((2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalene-2,7-diol; 
 [3-(7-hydroxy-6-{6-[methyl-(2,2,6,6-tetra methyl-piperidin-4-yl)-amino]-pyridazin-3-yl}-naphthalen-2-yloxy)-propyl]-carbamic acid tert-butyl ester; 
 7-(3-amino-propoxy)-3-{6-[methyl-(2,2,6,6-tetramethyl-piperidin-4-yl)-amino]-pyridazin-3-yl}naphthalen-2-ol; 
 N-[3-(7-hydroxy-6-{6-[methyl-(2,2,6,6-tetra methyl-piperidin-4-yl)-amino]-pyridazin-3-yl}naphthalen-2-yloxy)-propyl]-acetamide; 
 7-(3-hydroxypropoxy)-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 7-(3-methoxypropoxy)-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 7-(2-morpholinoethoxy)-3-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)naphthalen-2-ol; 
 3-(6-(piperidin-4-ylmethyl)pyridazin-3-yl)naphthalen-2-ol; 
 5-(1H-pyrazol-1-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)methyl)pyridazin-3-yl)phenol; 
 3-methoxy-2-(6-(methyl(2,2,6-trimethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(5-methyloxazol-2-yl)phenol; 
 2-(6-((6S)-6-((S)-1-hydroxyethyl)-2,2-dimethylpiperidin-4-yloxy)pyridazin-3-yl)-5-(1H pyrazol-1-yl)phenol; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-2-naphthonitrile; 
 3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-7-(piperidin-1-ylmethyl)naphthalen-2-ol; 
 3-(6-(methyl(2,2,6,6-t etraethylpiperidin-4-yl)amino)pyridazin-3-yl)-7-(pyrrolidin-1-ylmethyl)naphthalen-2-ol; 
 1-bromo-6-(6-(methyl(2,2,6,6-tetraet hylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalene-2,7-diol; 
 1-chloro-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalene-2,7-diol; 
 7-methoxy-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 7-methoxy-3-(6-(methyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 7-(3,6-dihydro-2H-pyran-4-yl)-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)naphthalen-2-ol; 
 7-(difluoromethyl)-3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 7-((4-hydroxy-2-methyl butan-2-yl)oxy)-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 7-(3-hydroxy-3-methylbutoxy)-3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol; 
 2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)benzene-1,3-diol; 
 3-methoxy-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H pyrazol-4-yl)phenol; 
 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-3-(trifluoromethoxy)phenol; 
 2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)-3-(trifluoromethoxy)phenol; 
 2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)-3-(trifluoromethoxy)phenol; 
 4-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(trifluoromethoxy)phenyl)-1-methylpyridin-2(1H)-one; 
 3-methoxy-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol; 
 3-methoxy-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl)phenol; 
 3-methoxy-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazn-3-yl)-5-(pyridin-3-yl)phenol; 
 5-(1-cyclopentyl-1H-pyrazol-4-yl)-3-methoxy-2-(6-(methyl(2,2,6,6-tetra methylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 3′ 5-dimethoxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-[1,1′-biphenyl]-3-ol; 
 3-(benzyloxy)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(5-methyloxazol-2-yl)phenol; 
 3-ethoxy-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(5-methyloxazol-2-yl)phenol; 
 5 3-(cyclopropylmethoxy)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)-pyridazin-3-yl)-5-(5-methyloxazol-2-yl)phenol; 
 2-methyl-5-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-1H benzo[d]imidazol-6-ol; 
 5-chloro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(1H-pyrazol-1-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 3-hydroxy-4-(6-((2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)benzonitrile; 
 2-(6-((2,2-dimethylpiperidin-4-yl)oxy)pyridazin-3-yl)-5-(1H-pyrazol-1-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(1H-pyrazol-4-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(4, 5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)phenol; 
 4-(1H-indol-2-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 4-(cyclopent-1-en-1-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(1H-pyrazol-3-yl)phenol; 
 4-(4-hydroxy-3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3 yl)phenyl)pyridin-2-ol; 
 4-(4-hydroxy-3-(6-((2,2,6,6-tetra methylpiperidin-4-yl)oxy)pyridazin-3-yl)phenyl)-1-methylpyridin-2-(1H)-one; 
 4-(4-hydroxy-3-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenyl)pyri din-2-ol; 
 5-(1H-indazol-7-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 4-chloro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol; 
 4-fluoro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol; 
 5-fluoro-4-(1H-imidazol-4-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-fluoro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(1H-pyrazol-4-yl)phenol; 
 5-fluoro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(1H-pyrazol-5-yl)phenol; 
 5,6-hydroxy-5-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-2,3-dihydro-1H-inden-1-one; 
 6-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-ol; 
 6-hydroxy-5-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-2,3-dihydro-1H-inden-1-one oxime hydrochloride salt; 
 5-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-2,3-dihydro-1H-indene-1,6-diol; 
 2-amino-6-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-8H-indeno[1,2-d]thiazol-5-ol hydrochloride salt; 
 9-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5,6-dihydroimidazo[5, 1-a]isoquinolin-8-ol hydrochloride salt; 
 4-hydroxy-3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)benzamide; 
 4-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)methyl)pyridazin-3-yl)phenol; 
 6-(3-(benzyloxy)isoquinolin-6-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 6-(1-(benzyloxy)isoquinolin-7-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 3-fluoro-5-(2-methoxypyridin-4-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol hydrochloride salt; 
 4-(3-fluoro-5-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)pyridin-2(1H)-one hydrochloride salt; 
 4-(3-fluoro-5-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one hydrochloride salt; 
 5-(3-fluoro-5-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one hydrochloride salt; 
 3-fluoro-5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol hydrochloride salt; 
 5-chloro-3-fluoro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol hydrochloride salt; 
 3-fluoro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol hydrochloride salt; 
 3-fluoro-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H pyrazol-4-yl)phenol hydrochloride salt; 
 5-(5-methoxypyridin-3-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(3-hydroxy-4-(6-methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl) phenyl)pyridin-2-ol; 
 4-(3-hydroxy-4-(6-methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)pyridin-2-ol; 
 5-(6-methoxypyridin-3-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-3-(trifluoromethyl)pyridin-2-ol; 
 5-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 4-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 5-(2-methoxypyridin-4-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 4-(3-hydroxy-4-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenyl)pyridin-2-ol; 
 5-(6-(dimethylamino)pyridin-3-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 4-(3-hydroxy-4-(6-((2,2,6,6-tetra methylpiperidin-4-yl)oxy)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(pyrimidin-5-yl)phenol; 
 5-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl) phenyl)pyridin-3-ol; 
 1-cyclopropyl-4-(3-hydroxy-4-(6-(methyl(2,2,6,6-tetra methylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)pyridin-2(1H)-one; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1,2,3,6-tetrahydropyridin-4-yl)phenol; 
 5-(cyclopent-1-en-1-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(3, 6-dihydro-2H-pyran-4-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(imidazo[1,5-a]pyridin-7-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(imidazo[1,2-a]pyridin-7-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(2-methylpyridin-4-yl)phenol; 
 5-(1H-imidazol-2-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(1H-imidazol-4-yl)-2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 5-(imidazo[1,2-a]pyrazin-3-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(4-methyl-1H-imidazol-2-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H-imidazol-4-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H imidazol-5-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(4-nitro-1H-imidazol-2-yl)phenol; 
 2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(2-methyl-1H imidazol-4-yl)phenol; 
 5-(1,2-dimethyl-1H-imidazol-4-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol; 
 1-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1H-pyrazole-4-carboxamide; 
 2-(6-((3aR,6aS)-5-(2-hydroxyethyl)hexahydropyrrolo[3,4-c]pyrrol-2 (1H)-yl)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol; 
 2-(6-((3 aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol; 
 2-(6-((3 aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)pyridazin-3-yl)-5-(1 Hpyrazol-4-yl)phenol; 
 4-(3-hydroxy-4-(6-(5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 4-(3-hydroxy-4-(6-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 2-(6-(2, 7-diazaspiro[4.5]decan-2-yl)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol; and 
 4-(4-(6-(2,7-diazaspiro[4.5]decan-2-yl)pyridazin-3-yl)-3-hydroxyphenyl)-1-methylpyridin-2(1H)-one; 
 5-(2-Methoxy-4-(1H-pyrazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 6-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)naphthalen-2-ol; 
 5-(2-Methoxyquinolin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(3-Methoxynaphthalen-2-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-Methoxy-4-(1H-pyrazol-1-yl)phenyl)-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-Methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-Methoxy-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 4-(3-Methoxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 5-(3-Methoxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)pyridin-2-ol; 
 5-(3-Methoxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 N-Methyl-5-(2-methyl-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 1-Methyl-4-(4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-3-(trifluoromethoxy)phenyl)pyridin-2(1H)-one; 
 5-(4-(3,5-Dimethyl-1H-pyrazol-4-yl)-2-methoxyphenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-Methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 2-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol; 
 2-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-1-yl)phenol; 
 5-(3-Hydroxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 4-(3-Hydroxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 5-(3-Hydroxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)pyridin-2-ol; 
 3-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)naphthalene-2,7-diol; 
 3-(5-((3aR,6aS)-Hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazol-2-yl)naphthalene-2,7-diol; 
 3-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)naphthalen-2-ol hydrobromide salt; 
 3-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinolin-2-ol; 
 2-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-4-(1H-pyrazol-1-yl)phenol; 
 5-(2-Chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 3-Chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol; 
 5-(2-Chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 3-Methoxy-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(5-methyloxazol-2-yl)phenol; 
 2-(2-Methoxy-4-(1H-pyrazol-1-yl)phenyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1,3,4-thiadiazole; 
 2-(5-(piperazin-1-yl)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-1-yl)phenol; 
 5-(7-Methoxyquinolin-6-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 6-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinolin-7-ol; 
 3-methoxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)benzonitrile; 
 3-fluoro-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)benzonitrile; 
 methyl 3-fluoro-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)benzoate; 
 5-(2-methoxy-4-(3-(methyl amino)-1H-pyrazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 7-methoxy-6-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinoline-2-carbonitrile; 
 4-(3-methoxy-4-(5-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 4-(3-chloro-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one; 
 5-(2-Chloro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-Chloro-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 N-methyl-5-(5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine Hydrochloride salt; 
 2-(2-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)-1,3,4-thiadiazole; 
 5-(2-chloro-4-(6-methoxypyridin-3-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(4-(6-aminopyridin-3-yl)-2-fluorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-fluoro-4-(3-methyl-1H-pyrazol-5-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-fluoro-4-(1H-pyrazol-5-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2,3-difluoro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2,3-difluoro-4-(1H-pyrazol-5-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2, 5-difluoro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2, 5-difluoro-4-(1H-pyrazol-5-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 2-(2, 5-difluoro-4-(1H-pyrazol-4-yl)phenyl)-5-((3 aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole; 
 5-(2-chloro-5-fluoro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(3-fluoro-5-(1H-pyrazol-4-yl)pyridin-2-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(4-(2-aminopyrimidin-4-yl)-2-chlorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(5-(2-aminopyrimidin-4-yl)-2-chlorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(4-(2,4-dimethylthiazol-5-yl)-2, 5-difluorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(4-(2,4-dimethylthiazol-5-yl)-2,3-difluorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 4-(3-hydroxy-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(trifluoromethoxy)phenyl)-1-methylpyridin-2(1H)-one; 
 5-(2-fluoro-6-methoxy-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 2-(2-fluoro-6-methoxy-4-(1H-pyrazol-4-yl)phenyl)-5-((3 aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole; 
 5-(2,3-difluoro-6-methoxy-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 6-methoxy-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-3,4-dihydroisoquinolin-1 (2H)-one; 
 5-(2-Chloro-4-(1H-pyrazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-Chloro-4-(1H-1,2,3-triazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-chloro-4-(2H-1,2,3-triazol-2-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-chloro-4-(1H-1,2,4-triazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(4-(3-amino-1H-pyrazol-1-yl)-2-chlorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3 aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole; 
 5-(2-Chloro-4-(1H-imidazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-fluoro-4-(1H-imidazol-1-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-methoxy-4-(1H-pyrazol-5-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(4-(2,4-dimethylthiazol-5-yl)-2-methoxyphenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-methoxy-4-(pyridin-3-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-fluoro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-methoxy-4-(2-methoxypyridin-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 5-(2-methoxy-4-(6-methoxypyridin-3-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 2-(2-Chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole; 
 2-(2-chloro-4-(1H-pyrazol-4-yl)phenyl)-5-((3 aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole; 
 2-(2-Chloro-4-(1H-pyrazol-4-yl)phenyl)-5-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-1,3,4-thiadiazole; 
 1-(4-(5-(2-chloro-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)morpholin-2-yl)-N,N-dimethylmethanamine; 
 2-(2-chloro-4-(1H-pyrazol-4-yl)phenyl)-5-(2-methyl-2,7-diazaspiro[4.5]decan-7-yl)-1,3,4-thiadiazole; 
 2-(2-fluoro-4-(1H-pyrazol-4-yl)phenyl)-5-((3 aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole; 
 2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(2,6-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazole; 
 2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-5-(2, 7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazole; 
 2-(5-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-1-yl)phenol; 
 5-(3-chloro-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)pyridin-2(1H)-one; 
 2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(3-(methylamino)-1H-pyrazol-1-yl)phenol; 
 3-fluoro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-4-yl)phenol; 
 3,4-difluoro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-4-yl)phenol; 
 6-hydroxy-5-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-2,3-dihydro-1H-inden-1-one; 
 2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-4-yl)phenol; 
 2-(5-(2,6-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol; 
 2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol; 
 3-fluoro-2-(5-((3 aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-4-yl)phenol Di-hydrochloride salt; 
 3-Chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1H-pyrazol-4-yl)phenol; 
 2-(2-methoxy-4-(1H-pyrazol-1-yl)phenyl)-5-((2,2,6,6-tetramethylpiperidin-4-yl)methyl)-1,3,4-thiadiazole; 
 2-(2,3-difluoro-4-(1H-pyrazol-4-yl)phenyl)-5-(2, 7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazole; 
 2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol; 
 4-methoxy-1-methyl-3-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinolin-2(1H)-one; 
 4-hydroxy-1-methyl-3-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinolin-2(1H)-one; 
 3-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinolin-2(1H)-one; 
 1-methyl-3-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)quinolin-2(1H)-one; 
 2-(2-Chloro-4-(1H-pyrazol-4-yl)phenyl)-5-((3 aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)yl)-1,3,4-thiadiazole Hydrochloride Salt; 
 2-(2-Chloro-4-(1H-pyrazol-4-yl)phenyl)-5-(2, 7-diazaspiro[4.5]decan-2-yl)-1,3,4-thiadiazole Hydrochloride Salt; 
 (R)-(4-(5-(2-chloro-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)piperazin-2-yl)methanol Hydrochloride Salt; 
 2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)benzo[b]thiophene-5-carbonitrile; and 
 5-(3-chlorobenzo[b]thiophen-2-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-2(1H)-one; 
 6-(6-((3 aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)pyridazin-3-yl)quinolin-7-ol; 
 7-hydroxy-1-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-2(1H)-one; 
 6-(6-(methyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-morpholinoquinolin-7-ol; 
 4-chloro-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 3-bromo-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 3-ethyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 3-(1H-imidazol-1-yl)-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-3-(1-methyl-1H-imidazol-4-yl)quinolin-7-ol; 
 3-isopropyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-3,7-diol; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-3-carbonitrile; 
 6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 4-(dimethyl amino)-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 3-chloro-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 4-methoxy-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 6-(3-(benzyloxy)isoquinolin-6-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 8-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinoline-1, 6-diol; 
 7-(6-(methyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 1-cyclopropyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 6-(1-(benzyloxy)isoquinolin-7-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine; 
 7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 2-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(1-methyl-1Hpyrazol-4-yl)quinolin-7-ol; 
 2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 4-ethoxy-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 4-chloro-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)quinolin-7-ol; 
 3-chloro-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 3-bromo-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 3-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 5-bromo-3-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-6-ol; 
 6-hydroxy-1-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-4(1H)-one; 
 2,3-dimethyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoxalin-6-ol; 
 2-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoxalin-6-ol; 
 3-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoxalin-6-ol; 
 4-methoxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 4-(azetidin-1-yl)-2-methyl-6-(6-(methyl(2, 2, 6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 7-hydroxy-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-4-carbonitrile; 
 4-cyclopropyl-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 4-(3,6-dihydro-2H-pyran-4-yl)-2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(tetrahydro-2Hpyran-4-yl)quinolin-7-ol; 
 2-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-4-(oxetan-3-yl)quinolin-7-ol; 
 4-(dimethyl amino)-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinolin-7-ol; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinazolin-4(1H)-one; 
 6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinazolin-7-ol; 
 7-hydroxy-1-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-3,4-dihydroquinolin-2(1H)-one; 
 7-hydroxy-1-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-3,4-dihydroquinolin-2(1H)-one; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinoline-1-carbonitrile; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-2-carbonitrile; 
 6-hydroxy-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-2-carbonitrile; 
 6-hydroxy-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinoline-1-carboxamide; 
 7-hydroxy-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-2-carboxamide; 
 6-hydroxy-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-2-carboxamide; 
 methyl6-hydroxy-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinoline-2-carboxylate; 
 6-hydroxy-7-(6-(piperazin-1-yl)pyridazin-3-yl)quinoline-2-carbonitrile; 
 7-hydroxy-6-(6-(piperazin-1-yl)pyridazin-3-yl)quinoline-2-carbonitrile; 
 7-(6-(piperazin-1-yl)pyridazin-3-yl)isoquinolin-6-ol; 
 7-(6-(1,2,3,6-tetrahydropyridin-4-yl)pyridazin-3-yl)quinolin-6-ol; 
 1-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-7-ol; 
 1-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 1,3-dimethyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 7-hydroxy-3-methyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinoline-1-carbonitrile; 
 1-amino-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 7-hydroxy-1,3-dimethyl-6-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)quinazoline-2,4(1H,3H)-dione; 
 6-hydroxy-5-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)benzo[d]oxazoi-2(3H)-one; 
 2-methyl-5-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-2H-indazol-6-ol; 
 1-methyl-5-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-1H-indazol-6-ol; 
 6-hydroxy-2-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-1 (2H)-one; 
 2-ethyl-6-hydroxy-7-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)isoquinolin-1(2H)-one; 
 1-ethoxy-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 7-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)isoquinoline-1,6-diol; 
 7-(6-(methyl(2,2,6,6-tetramethyl-piperidin-4-yl)amino)-pyridazin-3-yl)-3-phenylisoquinolin-6-ol; 
 3-methyl-7-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 3-cyclopropyl-7-(6-(methyl(2,2,6,6-tetramethyl-piperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 3-isopropyl-7-(6-(methyl(2,2,6,6-tetramethyl-piperidin-4-yl)amino)pyridazin-3-yl)isoquinolin-6-ol; 
 3-propyl-7-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)-pyridazin-3-yl)isoquinolin-6-ol; 
 3-isopropyl-7-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)-pyridazin-3-yl)isoquinolin-6-ol; and 
 3-methyl-7-(6-(piperazin-1-yl)pyridazin-3-yl)isoquinolin-6-ol; 
 or a pharmaceutically acceptable salt thereof; 
 for use in the treatment, prevention and/or delay of progression of cancer. 
 
     
     
         18 . A FoxM1 gene splicing modifier selected from the group consisting of:
 3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol;   3-hydroxy-4-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)benzonitrile;   5-(1H-pyrazol-4-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenol   2-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol;   5-pyrazol-1-yl-2-[6-((2,2,6,6-tetramethylpiperidin-4-yloxy)-pyridazin-3-yl]-phenol;   5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol;   3-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)naphthalene-2,7-diol;   3-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalene-2,7-diol;   7-methoxy-3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)naphthalen-2-ol;   5-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one;   4-(3-hydroxy-4-(6-(methyl-(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)phenyl)-1-methylpyridin-2(1H)-one;   4-(3-chloro-4-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)phenyl)-1-methylpyridin-2(1H)-one;   5-(2-Chloro-4-(1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine;   5-(2, 5-difluoro-4-(1H-pyrazol-5-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine;   or a pharmaceutically acceptable salt thereof;   for use in the treatment, prevention and/or delay of progression of cancer.   
     
     
         19 . The FoxM1 gene splicing modifier according to  claim 1  or a pharmaceutically acceptable salt thereof for use in the treatment, prevention and/or delay of progression of cancer, wherein the FoxM1 gene splicing modifier induces a transcriptionally inactive FoxM1 variant. 
     
     
         20 . The FoxM1 gene splicing modifier according to  claim 1  or a pharmaceutically acceptable salt thereof for use in the treatment, prevention and/or delay of progression of cancer, wherein the FoxM1 gene splicing modifier induces the transcriptionally inactive FoxM1 variant FoxM1A. 
     
     
         21 . The FoxM1 gene splicing modifier according to  claim 1  or a pharmaceutically acceptable salt thereof for use in the treatment, prevention and/or delay of progression of cancer, wherein the FoxM1 gene is the human FoxM1 gene. 
     
     
         22 . The FoxM1 gene splicing modifier according to  claim 1  or a pharmaceutically acceptable salt thereof for use in the treatment, prevention and/or delay of progression of cancer, wherein the cancer is selected from the group consisting of cancer of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system. 
     
     
         23 . The FoxM1 gene splicing modifier according to  claim 1  or a pharmaceutically acceptable salt thereof for use in the treatment, prevention and/or delay of progression of cancer, wherein the cancer is selected from the group consisting of leukemia, acute myeloid leukemia, colon cancer, gastric cancer, macular degeneration, acute monocytic leukemia, breast cancer, hepatocellular carcinoma, cone-rod dystrophy, alveolar soft part sarcoma, myeloma, skin melanoma, prostatitis, pancreatitis, pancreatic cancer, retinitis, adenocarcinoma, adenoiditis, adenoid cystic carcinoma, cataract, retinal degeneration, gastrointestinal stromal tumor, Wegener's granulomatosis, sarcoma, myopathy, prostate adenocarcinoma, Hodgkin's lymphoma, ovarian cancer, non-Hodgkin's lymphoma, multiple myeloma, chronic myeloid leukemia, acute lymphoblastic leukemia, renal cell carcinoma, transitional cell carcinoma, colorectal cancer, chronic lymphocytic leukemia, anaplastic large cell lymphoma, kidney cancer, breast cancer, and cervical cancer. 
     
     
         24 . Use of a FoxM1 gene splicing modifier according to  claim 1  for the preparation of a medicament for the treatment, prevention and/or delay of progression of cancer. 
     
     
         25 . Use of a FoxM1 gene splicing modifier according to  claim 1  for the treatment, prevention and/or delay of progression of cancer. 
     
     
         26 . A method for the treatment, prevention and/or delay of progression of cancer comprising administering an effective amount of a FoxM1 gene splicing modifier according to  claim 1  to a subject. 
     
     
         27 . A pharmaceutical composition comprising a FoxM1 gene splicing modifier according to  claim 1  for use in the treatment, prevention and/or delay of progression of cancer. 
     
     
         28 . A combination comprising a therapeutically effective amount of a FoxM1 gene splicing modifier according to  claim 1  or a pharmaceutically acceptable salt thereof and one or more therapeutically active co-agents.