Compound of the avermectin family or of the milbemycin family for the treatment and/or prevention of atopic dermatitis

Abstract

A pharmaceutical composition is described that includes a compound of the avermectin family, possibly ivermectin, or a compound of the milbemycin family in a pharmaceutically acceptable carrier, for use in the treatment and/or prevention of atopic dermatitis.

1 . A pharmaceutical composition comprising a compound of the avermectin family or of the milbemycin family in a pharmaceutically acceptable carrier, effective in the treatment of atopic dermatitis. 
     
     
         2 . The pharmaceutical composition as defined by  claim 1 , wherein the compound of the avermectin family is selected from the group consisting of ivermectin, avermectin, abamectin, doramectin, eprinomectin and selamectin, aversectin B, AB or C, emamectin B1a, emamectin B1b and their derivatives. 
     
     
         3 . The pharmaceutical composition as defined by  claim 2 , wherein the compound of the avermectin family is ivermectin. 
     
     
         4 . The pharmaceutical composition as defined by  claim 1 , wherein the compound of the milbemycin family is selected from the group consisting of lepimectin, milbemectin, milbemycin oxime and moxidectin, 6′-ethyllepimectin, 6′-methyllepimectin and its derivatives or nemadectin α, β, γ or δ. 
     
     
         5 . The pharmaceutical composition as defined by  claim 1 , wherein the composition is effective in the treatment of atopic dermatitis in pregnant women, children and/or infants. 
     
     
         6 . The pharmaceutical composition as defined by  claim 5 , wherein the composition is effective in the treatment of atopic dermatitis in infants. 
     
     
         7 . The pharmaceutical composition as defined by  claim 1 , wherein the composition is administered by topical application. 
     
     
         8 . The pharmaceutical composition as defined by  claim 1 , wherein the composition is in the form of an emulsion, of a cream, of a lotion type, of a gel or of a solution. 
     
     
         9 . The pharmaceutical composition as defined by  claim 1 , wherein the composition comprises from 0.001% to 5% by weight of a compound of the avermectin family or of the milbemycin family relative to the total weight of the composition. 
     
     
         10 . The pharmaceutical composition as defined by  claim 9 , wherein the composition comprises in water: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   Ivermectin 
                   1.0 
                 
                     
                   Glycerol 
                   4.0 
                 
                     
                   Acrylate C10-30 alkyl acrylate 
                   0.2 
                 
                     
                   Methyl para-hydroxybenzoate 
                   0.2 
                 
                     
                   Disodium EDTA 
                   0.05 
                 
                     
                   Citric acid monohydrate 
                   0.05 
                 
                     
                   Isopropyl palmitate 
                   4.0 
                 
                     
                   Cetyl alcohol 
                   3.5 
                 
                     
                   Stearyl alcohol 
                   2.5 
                 
                     
                   Oleyl alcohol 
                   2.0 
                 
                     
                   Ceteareth-20 
                   3.0 
                 
                     
                   Sorbitan monostearate 
                   2.0 
                 
                     
                   Dimethicone 200 20 cs 
                   0.5 
                 
                     
                   Propyl para-hydroxybenzoate 
                   0.1 
                 
                     
                   Propylene glycol 
                   2.0 
                 
                     
                   Phenoxyethanol 
                   1.0 
                 
                     
                   10% sodium hydroxide 
                   qs pH 
                 
                     
                     
                 
                     
                   as % by weight relative to the total weight of the composition. 
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         11 . The pharmaceutical composition as defined by  claim 9 , wherein the composition comprises from 0.00% 1 to 0.3% by weight of a compound of the avermectin family or of the milbemycin family relative to the total weight of the composition. 
     
     
         12 . The pharmaceutical composition as defined by  claim 10 , wherein the composition comprises from 0.001% to 0.05% by weight of a compound of the avermectin family or of the milbemycin family relative to the total weight of the composition. 
     
     
         13 . The pharmaceutical composition as defined by  claim 1 , wherein the composition comprises from 0.001% to 1% by weight of a compound of the avermectin family or of the milbemycin family relative to the total weight of the composition.