Prediction of preeclampsia using microrna

Abstract

The application relates to a method for predicting a risk for preeclampsia in a subject, said method comprising analysing a sample from the subject for the level of expression of miR455 and comparing the level of expression of miR455 in the sample from the subject to the levels of miR455 in a control sample, wherein a significantly lower expression of miR455 as compared to the expression of miR455 in the control is indicative of a risk for preeclampsia.

1 . A method for predicting a risk for preeclampsia in a subject, said method comprising:
 (a) analysing a sample from the subject for the level of expression of miR455 and,   (b) comparing the level of expression of miR455 in the sample from the subject to the levels of miR455 in a control sample, wherein a significantly lower expression of miR455 as compared to the expression of miR455 in the control is indicative of a risk for preeclampsia.   
     
     
         2 . The method of  claim 1  wherein the expression of miR210 is also analysed in the sample from the subject and wherein the combination of a significantly lower expression of miR455 and a significantly higher expression of miR210, as compared to the control sample, is indicative of a risk for preeclampsia. 
     
     
         3 . The method of  claim 2 , wherein the ratio of the expression of miR210 divided by the expression of miR455 is determined and wherein a ratio greater than 1 is indicative of a risk for preeclampsia. 
     
     
         4 . The method of  claim 1  wherein the sample comprises placenta tissue. 
     
     
         5 . The method of  claim 1  wherein the sample is a blood sample. 
     
     
         6 . The method of  claim 1  wherein the subject is human. 
     
     
         7 . A kit for performing the method of comprising:
 (i) means for analysing in a sample from a subject the level of expression of miR455; and, optionally,   (ii) means for analysing in a sample from a subject the level of expression of miR210, and, optionally   (iii) means for comparing the level of said miRNAs, i. e. miR455, and, optionally miR210, in a control sample.   
     
     
         8 - 10 . (canceled)