US2016369142A1PendingUtilityA1

Biological Buffers with Wide Buffering Ranges

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Assignee: DALY THOMAS PPriority: Apr 17, 2008Filed: Sep 2, 2016Published: Dec 22, 2016
Est. expiryApr 17, 2028(~1.8 yrs left)· nominal 20-yr term from priority
Inventors:Thomas Daly
C07D 295/088C09K 3/00C11D 1/66C07C 219/06C07D 295/15C07C 217/28C07C 217/08C07F 9/091C07C 229/22C07F 9/58C07C 215/08C07C 217/48C07C 309/14C07C 219/22C07C 205/40C07C 229/12C07D 213/74C07C 205/15C07F 9/3817C07F 9/3808
52
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Claims

Abstract

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

Claims

exact text as granted — not AI-modified
I claim: 
     
         1 . The biological buffer of the following structure: 
       
         
           
           
               
               
           
         
         Where, A, D, are independently chosen from —H, —CH3, —CH2CH3, —CH2CH2CH3, —CH2OH, —CH2O(CH2CH2CH2N) n H where n and m are integers greater than zero. 
       
     
     
         2 . The biological buffer of  claim 1  wherein A is —H and D is —CH3. 
     
     
         3 . The biological buffer of  claim 1  wherein A is —H and D is —CH2CH3. 
     
     
         4 . The biological buffer of  claim 1  wherein A is —H and D is —CH2CH2CH3. 
     
     
         5 . The biological buffer of  claim 1  wherein A is —H and D is —CH2OH. 
     
     
         6 . The biological buffer of  claim 1  wherein A is —H and D is —CH3. 
     
     
         7 . The biological buffer of  claim 1  wherein A is —CH3 and D is —CH2CH3. 
     
     
         8 . The biological buffer of  claim 1  wherein A is —CH3 and D is —CH2CH2CH3. 
     
     
         9 . The biological buffer of  claim 1  wherein A is —CH3 and D is —CH2OH. 
     
     
         10 . The biological buffer of  claim 1  wherein A is —CH2CH3 and D is —CH2CH2CH3.11. 
     
     
         11 . The biological buffer of  claim 1  wherein A is —CH2CH3 and D is —CH2OH. 
     
     
         12 . The biological buffer of  claim 1  wherein A is —CH2CH2CH3 and D is —CH2OH 
     
     
         13 . The biological buffer of the following structure: 
       
         
           
           
               
               
           
         
         Where A is chosen from —CH2COOH, —CH2CH2COOH, —CH2CH(CH3)COOH, —CH2CH2SO3H. 
       
     
     
         14 . The surfactant of the following structure: 
       
         
           
           
               
               
           
         
         Where R is alkyl, saturated or unsaturated, cyclic or acyclic, branched or linear from 2-22 carbons; A, D are independently chosen from —H, —CH3, —CH2CH3, —CH2CH2CH3, —CH2OH. 
       
     
     
         15 . The surfactant of  claim 14  wherein A is —H and D is —CH3. 
     
     
         16 . The surfactant of  claim 14  wherein A is —CH3 and D is chosen from —CH3, —CH2CH3, —CH2CH2CH3, —CH2OH. 
     
     
         17 . The surfactant of  claim 14  wherein A is —CH3 and D is chosen from —CH2CH2CH3, —CH2OH. 
     
     
         18 . The surfactant of  claim 14  wherein A is —CH3 and D is —CH2OH.

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