Nasal delivery

Abstract

A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal cavity of a subject and comprising an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject; and a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.

1 - 78 . (canceled) 
     
     
         79 . A delivery device for delivering a substance to a nasal cavity of a subject for systemic uptake, the delivery device comprising:
 a nosepiece for insertion into the nasal cavity of the subject, the nosepiece including an outlet unit comprising:
 a first nozzle; 
 a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into anterior and posterior regions such that substantially all of the substance is delivered from the first nozzle to the anterior region, and 
 a delivery channel through which a gas flow is delivered to the anterior region; 
   a mouthpiece in fluid communication with the nosepiece through which the subject exhales to cause closure of an oropharyngeal velum of the subject;   a substance supply unit operable to deliver the substance to the first nozzle; and   a gas unit operable to supply the gas flow to the delivery channel.   
     
     
         80 . The delivery device of  claim 79 , wherein the substance supply unit is breath actuated on oral exhalation by the subject. 
     
     
         81 . The delivery device of  claim 79 , wherein the substance supply unit is breath actuated on nasal exhalation by the subject. 
     
     
         82 . The delivery device of  claim 79 , wherein the substance supply unit is manually actuated. 
     
     
         83 . The delivery device of  claim 79 , wherein the outlet unit further comprises a second nozzle. 
     
     
         84 . The delivery device of  claim 79 , wherein the first nozzle is substantially laterally directed so as to direct the substance to a lateral surface within the anterior region of the nasal cavity. 
     
     
         85 . The delivery device of  claim 79 , wherein the nozzle is configured to deliver a liquid. 
     
     
         86 . The delivery device of  claim 79 , wherein the nozzle is configured to deliver a powder. 
     
     
         87 . The delivery device of  claim 79 , wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve. 
     
     
         88 . The delivery device of  claim 79 , wherein the posterior nosepiece member is configured to close the nasal valve of the subject. 
     
     
         89 . A method of delivering a substance to a nasal cavity of a subject for systemic uptake, the method comprising:
 inserting a nosepiece into the nasal cavity of the subject, the nosepiece including an outlet unit having a first nozzle, a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into anterior and posterior regions such that substantially all of the substance is delivered from the first nozzle to the anterior region, and a delivery channel through which a gas flow is delivered to the anterior region;   inserting a mouthpiece through which the subject exhales to cause closure of an oropharyngeal velum of the subject into the mouth of the subject;   delivering the substance from a substance supply unit to the first nozzle; and   supplying the gas flow to the delivery channel.   
     
     
         90 . The method of  claim 89 , wherein the first nozzle is substantially laterally directed so as to direct the substance to a lateral surface within the anterior region of the nasal cavity. 
     
     
         91 . The method of  claim 89 , wherein the nozzle is configured to deliver a liquid. 
     
     
         92 . The method of  claim 89 , wherein the nozzle is configured to deliver a powder. 
     
     
         93 . The method of  claim 89 , further comprising the step of delivering the substance through the first nozzle to the anterior region of the nasal cavity of the subject. 
     
     
         94 . The method of  claim 89 , further comprising the step of delivering the gas flow through the delivery channel to the anterior region of the nasal cavity of the subject. 
     
     
         95 . The method of  claim 93 , further comprising the step of delivering the gas flow through the delivery channel to the anterior region of the nasal cavity of the subject. 
     
     
         96 . The method of  claim 95 , wherein the step of delivering the gas flow through the delivery channel to the anterior region of the nasal cavity of the subject and the step of delivering the substance through the first nozzle to the anterior region of the nasal cavity of the subject occur substantially simultaneously. 
     
     
         97 . The method of  claim 89 , wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve. 
     
     
         98 . The method of  claim 89 , wherein the posterior nosepiece member is configured to close the nasal valve of the subject.