Immunogenic Compositions

Abstract

The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci , or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis . The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis ) in a subject, by administering to the subject a composition of the invention.

1 . An immunogenic composition comprising a Chlamydial major outer membrane protein, or an immunogenic fragment thereof, from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises at least the product E6020 having CAS Registry Number 287180-63-6. 
     
     
         2 . The composition of  claim 1 , comprising at least one carrier system. 
     
     
         3 . The composition of  claim 2 , wherein the carrier system comprises an emulsion, preferably an oil-in-water emulsion. 
     
     
         4 . The composition of  claim 2 , wherein the carrier system comprises a mineral particle, and preferably an aluminum salt. 
     
     
         5 . The composition of  claim 3 , wherein the carrier system comprises a mineral particle, and preferably an aluminum salt. 
     
     
         6 . The composition of  claim 1 , comprising at least an immunostimulant, and optionally a Toll-like receptor 7/8 agonist. 
     
     
         7 . The composition of  claim 1 , wherein the major outer membrane protein is from at least one serovar of  C. trachomatis.    
     
     
         8 . The composition of  claim 7 , wherein the major outer membrane protein is selected from  C. trachomatis  serovars: E, D, F, G, H, I, J, K, L1, L2, and L3. 
     
     
         9 . The composition of  claim 8  wherein the major outer membrane protein is from serovar E. 
     
     
         10 . The composition of  claim 1  wherein the major outer membrane protein is recombinantly derived. 
     
     
         11 . The composition of  claim 7 , comprising at least three major outer membrane proteins from  C. trachomatis  each selected from serovars: E, D, F, G, H, I, J, K, L1, L2, and L3. 
     
     
         12 . The composition of  claim 11 , wherein the composition comprises three major outer membrane proteins, one from serovar E, one from serovar D and one from serovar F. 
     
     
         13 - 15 . (canceled) 
     
     
         16 . A method of eliciting an immune response in a subject, comprising administering to the subject an effective amount of a composition comprising a Chlamydial major outer membrane protein, or an immunogenic fragment thereof, from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises at least the product E6020 having CAS Registry Number 287180-63-6. 
     
     
         17 . A method of manufacturing a vaccine comprising (a) preparing an oil-in-water emulsion that comprises the product E6020 having CAS Registry Number 287180-63-6, (b) adding to the prepared emulsion a  Chlamydia  major outer membrane protein from at least one Chlamydial serovar.