US2016367593A1PendingUtilityA1

Liquid chalcogenide compositions and methods of manufacturing and using the same

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Assignee: HUTCHINSON FRED CANCER RESPriority: Oct 5, 2006Filed: Jan 25, 2016Published: Dec 22, 2016
Est. expiryOct 5, 2026(~0.2 yrs left)· nominal 20-yr term from priority
Inventors:Kevin TomaselliPaul A. HillThomas L. DeckwerthEdward A. WintnerCsaba Szabo
A61K 33/04A61K 9/08A61K 33/00B65D 81/2069A61J 1/06A61P 43/00A61P 39/00A61K 9/0019A61K 47/02A61K 47/12A61K 33/24
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Claims

Abstract

The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.

Claims

exact text as granted — not AI-modified
1 . A sterile, stable aqueous pharmaceutical composition comprising: a solution of deoxygenated water and sodium sulfide; wherein the sodium sulfide produces Na2S, H2S and HS—; wherein the solution further comprises sulfide oxidation products selected from the group consisting of polysulfide, sulfite, sulfate and thiosulfate; and wherein the oxidation products comprise sulfate in the range of 0%-1.0%, sulfite in the range of 0%-1.0%, polysulfide in the range of 0%-2.0% or thiosulfate in the range of 0%-1.0%. 
     
     
         2 . The composition of  claim 1  wherein said HS— has a concentration in the range of 50 mM to 150 mM. 
     
     
         3 . The composition of  claim 1  wherein said HS— has a concentration in the range of 65 mM to 75 mM. 
     
     
         4 . The composition of  claim 1  wherein said HS— has a concentration in the range of 68-72 mM. 
     
     
         5 . The composition of  claim 1  wherein said HS— is present in amounts ranging from about 95% to about 100% by w/v. 
     
     
         6 . The composition of  claim 1  which is stable for a storage period of about 6 months at a temperature range of 23°-27° C. 
     
     
         7 . The composition of  claim 1  wherein said composition has an osmolarity in the range of 250-330 mOsmol/L. 
     
     
         8 . The composition of  claim 1 , wherein said composition is near isotonic. 
     
     
         9 . The composition of  claim 1 , wherein said composition further comprises a pH modifying agent. 
     
     
         10 . The composition of  claim 9 , wherein said pH modifying agent is selected from the group consisting of: carbon dioxide, sodium hydroxide, hydrochloric acid or hydrogen sulfide. 
     
     
         11 . The composition of  claim 1  which has an oxygen content of less than or equal to 5 μM for about six months. 
     
     
         12 . The composition of  claim 1  wherein said composition is stored in an impermeable container. 
     
     
         13 . A kit comprising one or more containers comprising a composition of a sulfide, wherein said composition has a pH in the range of 6.5 to 8.5. 
     
     
         14 . The kit of  claim 13 , wherein said composition is isotonic. 
     
     
         15 . The kit of  claim 13 , wherein said containers are light protective. 
     
     
         16 . The kit of  claim 13 , wherein said containers are amber vials. 
     
     
         17 . The kit of  claim 13 , wherein said containers are gas impermeable. 
     
     
         18 . The kit of  claim 13 , wherein said composition is stored in said container under an inert atmosphere or noble gas.

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