Compositions Including Androgen Receptor Degradation (ARD) Enhancers and Methods of Prophylactic or Therapeutic Treatment of Skin Disorders and Hair Loss

Abstract

The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions include an ARD enhancer in combination with a second compound or composition. In some embodiments the second compound is at least one of a bactericide, an antibiotic, an anti-microbial peptide, Vitamin A, a Vitamin A derivative, a retinoid, an anti-inflammatory compound, and anti-androgen compounds.

What is claimed is: 
     
         1 . A method of treating a subject for a skin disorder, comprising:
 a) administering to said subject a first compound comprising an ARD enhancer provided in a pharmaceutically acceptable carrier; and   b) administering to said subject a second compound comprising a bactericide, an antibiotic, an anti-microbial peptide, Vitamin A, a Vitamin A derivative, a retinoid, an anti-inflammatory compound, or a combination thereof, provided in a pharmaceutically acceptable carrier;   
       wherein said subject is treated for said skin disorder. 
     
     
         2 . The method of  claim 1 ,
 wherein said ARD enhancer comprises ASC-J9 or ASC-J15.   
     
     
         3 . The method of  claim 1 ,
 wherein said ARD enhancer comprises ASC-Q9, ASC-Q44, ASC-Q49, ASC-Q77, ASC-Q98, ASC-Q99, ASC-Q101, ASC-Q102, ASC-Q103, ASC-Q110, ASC-Q111, ASC-Q113, ASC-Q116, ASC-JM1, ASC-JM2, ASC-JM4, ASC-JM5, ASC-JM6, ASC-JM7, ASC-JM12, ASC-JM13, ASC-JM14, ASC-JM16, ASC-JM17, ASC-JM18, or ASC-JM19.   
     
     
         4 . The method of  claim 1 ,
 wherein said second compound comprises a retinoid.   
     
     
         5 . The method of  claim 1 ,
 wherein said skin disorder comprises acne, atopic dermatitis, rosacea, a wound, or wound healing.   
     
     
         6 . The method of  claim 1 ,
 wherein said skin disorder comprises acne or is acne.   
     
     
         7 . The method of  claim 1 ,
 wherein said skin disorder comprises rosacea.   
     
     
         8 . The method of  claim 1 ,
 wherein said skin disorder comprises atopic dermatitis.   
     
     
         9 . The method of  claim 1 ,
 wherein said skin disorder comprises a wound or wound healing.   
     
     
         10 . The method of  claim 1 ,
 wherein said first compound and said second compound are provided together.   
     
     
         11 . The method of  claim 1 ,
 wherein said first compound and said second compound are provided separately.   
     
     
         12 . The method of  claim 1 ,
 wherein said first compound and said second compound are administered together.   
     
     
         13 . The method of  claim 1 ,
 wherein said first compound and said second compound are administered separately.   
     
     
         14 . The method of  claim 1 ,
 wherein said first compound is provided in a topical formulation.   
     
     
         15 . The method of  claim 1 ,
 wherein said second compound is provided in a topical formulation.   
     
     
         16 . The method of  claim 1 ,
 wherein said first compound is provided in an injectable formulation.   
     
     
         17 . The method of  claim 1 ,
 wherein said second compound is provided in an injectable formulation.   
     
     
         18 . The method of  claim 1 ,
 wherein said first compound is provided in an oral formulation.   
     
     
         19 . The method of  claim 1 ,
 wherein said second compound is provided in an oral formulation.   
     
     
         20 . The method of  claim 1 ,
 wherein said first and second compounds are provided or administered together or separately in a topical formulation.