Gene signatures for cancer prognosis

Abstract

Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

1 - 26 . (canceled) 
     
     
         27 . A method of treating prostate cancer in a patient comprising:
 (1) obtaining a sample comprising prostate cancer tumor tissue from said patient;   (2) determining the expression of a panel of genes comprising NUSAP1 and UBE2C in said sample comprising prostate cancer tumor tissue;   (3) prognosing the individual as having a decreased likelihood of cancer progression when the expression of the genes NUSAP1 and UBE2C is lower than a threshold index value; and   (4) administering to said patient an effective amount of active surveillance based on the prognosis.   
     
     
         28 . The method of  claim 27 , wherein said determining step further comprises determining the expression of one or more housekeeping genes in said sample. 
     
     
         29 . The method of  claim 28 , wherein said determining step further comprises normalizing the expression of the genes NUSAP1 and UBE2C using the expression of the housekeeping genes. 
     
     
         30 . A method of treating prostate cancer in a patient comprising:
 (1) obtaining a sample comprising prostate cancer tumor tissue from said patient;   (2) determining the expression of a panel of genes comprising NUSAP1 and UBE2C in said sample comprising prostate cancer tumor tissue;   (3) prognosing the individual as having an increased likelihood of cancer progression when the expression of the genes NUSAP1 and UBE2C exceed a threshold index value; and   (4) administering to said patient an effective amount of one or more of chemotherapy, radiation therapy or surgery based on the prognosis.   
     
     
         31 . The method of  claim 30 , wherein said determining step further comprises determining the expression of one or more housekeeping genes in said sample. 
     
     
         32 . The method of claim  43 , wherein said determining step further comprises normalizing the expression of the genes NUSAP1 and UBE2C using the expression of the housekeeping genes.