US2016355505A1PendingUtilityA1

Novel compounds

Assignee: GLAXO GROUP LTDPriority: Mar 11, 2011Filed: Aug 19, 2016Published: Dec 8, 2016
Est. expiryMar 11, 2031(~4.6 yrs left)· nominal 20-yr term from priority
A61P 35/00A61P 37/00A61P 37/08A61P 37/06A61P 43/00A61P 7/00A61P 9/00A61P 29/00A61P 19/02A61P 17/04A61P 17/00A61P 17/02A61P 13/12A61P 19/04C07D 403/12C07D 401/12A61K 31/55A61K 9/0014A61K 45/06C07D 401/14A61K 31/4725
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Claims

Abstract

A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

Claims

exact text as granted — not AI-modified
1 . A compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         X is CR 1  or N; 
         Y is CH, C or N; 
         R 1  is hydrogen, C 1-6 alkoxy or C 1-6 alkyl; 
         R 2  is hydrogen, C 1-6 alkoxy, halo, —C(O)C 1-6 alkyl, CN, Halo-C 1-6 alkyl or C(O)NR 4 R 5 ; 
         R 3  is hydrogen or C 1-6 alkoxy; 
         R 4  is hydrogen or C 1-6 alkyl; 
         R 5  is hydrogen or C 1-6 alkyl; and 
         m and n are integers each independently selected from 1 and 2; or 
         a salt thereof.

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