Antibodies that bind novel pcsk9 variants

Abstract

The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

What is claimed is: 
     
         1 . An isolated antibody or antigen binding fragment thereof that binds to a polypeptide comprising SEQ ID NO:2. 
     
     
         2 . The isolated antibody of  claim 1 , wherein said antibody is a monoclonal antibody. 
     
     
         3 . The isolated antibody of  claim 1 , wherein said antibody is a polyclonal antibody. 
     
     
         4 . A pharmaceutical composition comprising a therapeutically effective amount of the antibody or antigen binding fragment of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
         5 . An isolated antibody or antigen binding fragment thereof that binds to a polypeptide comprising SEQ ID NO:4. 
     
     
         6 . The isolated antibody of  claim 5 , wherein said antibody is a monoclonal antibody. 
     
     
         7 . The isolated antibody of  claim 5 , wherein said antibody is a polyclonal antibody. 
     
     
         8 . A pharmaceutical composition comprising a therapeutically effective amount of the antibody or antigen binding fragment of  claim 5  and a pharmaceutically acceptable carrier.