Methods And Compositions For Modifying Sensorial Perception

Abstract

Compounds and methods for modifying sensory perception associated with transient sensory receptors TRPA1, TRPV1, and TRPA1V1. A method for screening compounds for modulation of TRPA1, TRPV1, and/or TRPA1V1. Compositions comprising TRPA1V1 agonists or antagonists, for modifying sensory perception of the compositions.

What is claimed is: 
     
         1 . A method of altering the sensory perception of burning, irritation, or pain from exposure to an oral care composition, the method comprising:
 incorporating a compound that modulates TRPA1V1 activity into an oral care composition;   wherein the compound is selected from the group consisting of ethyl vinyl ketone, vanillin propylene glycol acetal, bisabolene, and combinations thereof;   wherein the compound is present in an amount effective to reduce the activation of TRPA1V1 relative to the activation of at least one of TRPA1 or TRPV1.   
     
     
         2 . The method of  claim 1 , wherein the compound is ethyl vinyl ketone. 
     
     
         3 . The method of  claim 1 , wherein the compound is vanillin propylene glycol acetal. 
     
     
         4 . The method of  claim 1 , wherein the compound is bisabolene. 
     
     
         5 . The method of  claim 1 , wherein the oral care composition is selected from the group consisting of dentifrice, mouth rinse, lozenge, chewable tablet, chewing gum, and combinations thereof. 
     
     
         6 . A method of altering the sensory perception of burning, irritation, or pain from exposure to a personal care composition, the method comprising:
 incorporating a compound that modulates TRPA1V1 activity into a personal care composition;   wherein the compound is selected from the group consisting of ethyl vinyl ketone, vanillin propylene glycol acetal, bisabolene, trans,trans-2,4-undecadien-1-al, and combinations thereof;   wherein the personal care composition is selected from the group consisting of hair coloring compositions, cough and cold compositions, shower gels, lotions, moisturizers, sunscreens, shampoos, conditioners and combinations thereof;   wherein the compound is present in an amount effective to reduce the activation of TRPA1V1 relative to the activation of at least one of TRPA1 or TRPV1.   
     
     
         7 . The method of  claim 6 , wherein the compound is ethyl vinyl ketone. 
     
     
         8 . The method of  claim 6 , wherein the compound is vanillin propylene glycol acetal. 
     
     
         9 . The method of  claim 6 , wherein the compound is bisabolene. 
     
     
         10 . The method of  claim 6 , wherein the compound is trans,trans-2,4-undecadien-1-al.