Apparatus and methods for manipulation and optimization of biological systems

Abstract

A system includes a processor and a memory storing processor-executable instructions, which when executed by the processor direct the processor to provide control data indicating application of a stimulus to a biological system, obtain sensor data indicating measurements of a response of the biological system to the stimulus, determine fitting parameters of a biological system model based on the response of the biological system to the stimulus, and predict a magnitude of the stimulus that, when applied to the biological system, will yield an optimized response of the biological system based on the model.

What is claimed is: 
     
         1 . A system, comprising:
 a processor; and   a memory storing processor-executable instructions, which when executed by the processor direct the processor to:
 provide control data indicating application of a stimulus to a biological system; 
 obtain sensor data indicating measurements of a response of the biological system to the stimulus; 
 determine fitting parameters of a biological system model based on the response of the biological system to the stimulus; and 
 predict a magnitude of the stimulus that, when applied to the biological system, will yield an optimized response of the biological system based on the model. 
   
     
     
         2 . The system of  claim 1 , the instructions further comprising instructions to direct the processor to:
 determine, based on the model, predicted responses of applying varying magnitudes of the stimulus to the biological system;   obtain measured responses of the biological system to the varying magnitudes of the stimulus; and   determine ones of the fitting parameters by reducing deviations between the predicted responses and the measured responses.   
     
     
         3 . The system of  claim 1 , the instructions further comprising instructions to direct the processor to:
 determine a combination of stimuli to apply to the biological system based on the model; and   direct the combination of stimuli to be applied to the biological system.   
     
     
         4 . The system of  claim 3 , wherein the combination of stimuli include one or more of biochemical, electromagnetic, thermal, mechanical, and optical stimulation. 
     
     
         5 . The system of  claim 3 , wherein the combination of stimuli includes a combination of drugs. 
     
     
         6 . The system of  claim 1 , the instructions further comprising instructions to direct the processor to:
 determine a predicted response time of the biological system to the stimulus, based on the model.