Boron-Containing Small Molecules as Anti-Inflammatory Agents

Abstract

Compounds and methods of treating anti-inflammatory conditions are disclosed.

What is claimed is: 
     
         1 . A compound having a structure according to the formula: 
       
         
           
           
               
               
           
         
       
       wherein
 R a  is a member selected from CN, C(O)NR 1 R 2 , C(O)OR 3    
 wherein R 3  is a member selected from H and substituted or unsubstituted alkyl, 
 X is a member selected from N, CH and CR b , 
 R b  is a member selected from halogen and substituted or unsubstituted alkyl, C(O)R 4 , C(O)OR 4 , OR 4 , NR 4 R 5 , 
 wherein R 1 , R 2 , R 4  and R 5  are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, 
 with the proviso that R 1  and R 2 , together with the atoms to which they are attached, are optionally combined to form a 4- to 8-membered substituted or unsubstituted heterocycloalkyl ring 
 with the proviso that R 4  and R 5 , together with the atoms to which they are attached, are optionally combined to form a 4- to 8-membered substituted or unsubstituted heterocycloalkyl ring, 
 
       and salts thereof.