Compositions comprising terpene compounds for treating negative sensory phenomena

Abstract

Compositions comprising terpene compounds for the treatment of negative sensory phenomena (NSP). Negative sensory phenomena is characterized by a decreased ability to sense light touch, pin prick, vibration, temperature, pain and/or reduced proprioception. The terpene compounds are preferably aromatic terpene compounds such as geraniol and citronellol and analogs thereof. The terpenes may also be used in combination. The terpenes are derived form plant essential oils or are manufactured synthetically.

1 .- 31 . (canceled) 
     
     
         32 . A composition for the treatment of negative sensory phenomena in a mammalian subject comprising at least one terpene compound and, optionally, one or more pharmaceutically acceptable diluents or excipients, wherein the terpene compound is purified and/or synthetic. 
     
     
         33 . The composition of  claim 32 , wherein said terpene compound is geraniol, citronellol or a pharmaceutically acceptable isomer, salt, ester or solvate thereof. 
     
     
         34 . The composition of  claim 33 , wherein said terpene compound is geraniol. 
     
     
         35 . The composition of  claim 33 , wherein said terpene compound is citronellol. 
     
     
         36 . The composition of  claim 32 , wherein said terpene compound is geraniol and citronellol. 
     
     
         37 . The composition of  claim 32 , wherein the mammalian subject is a human. 
     
     
         38 . The composition of  claim 32 , wherein the composition is in the form of a suspension, pill, gel, oil, cream, patch, spray or aerosol. 
     
     
         39 . The composition of  claim 32 , wherein the composition is suitable for oral administration, topical administration, intranasal delivery, or transdermal administration. 
     
     
         40 . The composition of  claim 32 , wherein the negative sensory phenomena is associated with neuropathy. 
     
     
         41 . The composition of  claim 40 , wherein said neuropathy is caused by diabetic peripheral neuropathy, herpes zoster, post herpetic neuralgia, trigeminal neuralgia, complex regional pain syndrome, reflex sympathetic dystrophy, phantom limb syndrome, chronic disease (multiple sclerosis, HIV, etc), trauma (causalgja), impingement (e.g., sciatica, carpal tunnel, etc), drug exposure, toxic chemical exposure, current infection, past infection, impaired organ function, vascular disease, metabolic disease, cancer, cancer treatment, autoimmune disease, fibromylagia, or it is idiopathic. 
     
     
         42 . The composition of  claim 32 , wherein the negative sensory phenomena are characterized by a decreased ability to sense at least one of light touch, pin prick, vibration, hot, cold or pain and/or a reduced proprioception. 
     
     
         43 . The composition of  claim 33 , wherein the composition is in the form of a suspension, pill, gel, oil, cream, patch, spray or aerosol. 
     
     
         44 . The composition of  claim 33 , wherein the composition is suitable for oral administration, topical administration, intranasal delivery, or transdermal administration. 
     
     
         45 . The composition of  claim 33 , wherein the negative sensory phenomena is associated with neuropathy. 
     
     
         46 . The composition of  claim 45 , wherein said neuropathy is caused by diabetic peripheral neuropathy, herpes zoster, post herpetic neuralgia, trigeminal neuralgia, complex regional pain syndrome, reflex sympathetic dystrophy, phantom limb syndrome, chronic disease (multiple sclerosis, HIV, etc), trauma (causalgja), impingement (e.g., sciatica, carpal tunnel, etc), drug exposure, toxic chemical exposure, current infection, past infection, impaired organ function, vascular disease, metabolic disease, cancer, cancer treatment, autoimmune disease, fibromylagia, or it is idiopathic. 
     
     
         47 . The composition of  claim 33 , wherein the negative sensory phenomena are characterized by a decreased ability to sense at least one of light touch, pin prick, vibration, hot, cold or pain and/or a reduced proprioception. 
     
     
         48 . The composition of  claim 33 , wherein the mammalian subject is a human.