US2016310539A1PendingUtilityA1

Transdiscal Administration Of Specific Inhibitors Of Pro-Inflammatory Cytokines

Assignee: DEPUY SYNTHES PRODUCTS LLCPriority: May 13, 2003Filed: Jul 1, 2016Published: Oct 27, 2016
Est. expiryMay 13, 2023(expired)· nominal 20-yr term from priority
A61K 38/1875A61K 39/3955A61K 38/1841A61K 39/395C12Y 304/21005A61K 35/28A61K 47/34A61K 38/18A61K 38/17G01N 33/6869A61K 38/4833A61K 38/363A61K 45/06G01N 2333/54A61K 9/0085A61K 9/0012A61K 38/20A61K 9/0019A61K 35/32A61P 19/00A61B 17/7061A61K 38/1793
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Claims

Abstract

The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.

Claims

exact text as granted — not AI-modified
1 - 20 . (canceled) 
     
     
         21 . A method of treating a patient having a degenerating disc, comprising the step of:
 a) injecting into the disc a formulation comprising:
 i) cultured, allograft intervertebral disc cells; and 
 ii) fibrinogen; and 
   b) forming within the disc a fibrin matrix derived from the fibrinogen that provides a scaffold for new tissue growth.   
     
     
         22 . The method of  claim 21 , wherein the formulation further comprises iii) thrombin.

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