US2016310523A1PendingUtilityA1

Use of oxygen-containing gas source

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Assignee: UNIV CHINA MEDICALPriority: Apr 23, 2015Filed: Sep 7, 2015Published: Oct 27, 2016
Est. expiryApr 23, 2035(~8.7 yrs left)· nominal 20-yr term from priority
Inventors:Wei-Ta Lai (Ted Lai)
A61P 9/00A61P 43/00A61K 33/00A61K 45/06A61P 25/00A61K 9/007
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Claims

Abstract

A method of increasing blood-brain barrier permeability of a subject to a molecule is disclosed. The method includes causing the subject to inhale a gas source, and the gas source being effective for increasing blood-brain barrier permeability to the molecule, wherein the gas source includes at least 20 weight percent oxygen.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of increasing blood-brain barrier permeability of a subject to a molecule, the method comprising causing the subject to inhale a gas source that is effective for increasing blood-brain barrier permeability to the molecule, wherein the gas source comprises at least 20 weight percent oxygen. 
     
     
         2 . The method of  claim 1 , wherein the gas source further comprises at least 1 weight percent carbon dioxide. 
     
     
         3 . The method of  claim 2 , wherein a ratio of a weight/volume percent of the oxygen to the weight/volume percent of the carbon dioxide ranges from 1:1 to 1:20. 
     
     
         4 . The method of  claim 2 , wherein the gas source comprises 20 weight percent oxygen and 1 weight percent carbon dioxide. 
     
     
         5 . The method of  claim 2 , wherein the gas source comprises 20 weight percent oxygen and 20 weight percent carbon dioxide. 
     
     
         6 . The method of  claim 2 , wherein the gas source consists of 95 weight percent oxygen and 5 weight percent carbon dioxide. 
     
     
         7 . The method of  claim 2 , wherein the gas source consists of 90 weight percent oxygen and 10 weight percent carbon dioxide. 
     
     
         8 . The method of  claim 2 , wherein the gas source consists of 80 weight percent oxygen and 20 weight percent carbon dioxide. 
     
     
         9 . The method of  claim 1 , wherein the gas source is 100 weight percent oxygen. 
     
     
         10 . The method of  claim 1 , wherein the molecule is a diagnostic agent. 
     
     
         11 . The method of  claim 1 , wherein the molecule is a neuropharmaceutical agent.

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