Fibers, composition for producing fibers, and biomaterial containing fibers

Abstract

The invention provides a fiber which is superior in safety, can be conveniently produced, and has organic solvent resistance, as well as a starting material composition for producing the fiber and a biocompatible material containing the fiber. The fiber is produced by spinning a composition containing (A) a condensation product obtained by condensing one or more kinds of a compound represented by the formula (1), and (B) an acid compound: wherein each symbol is as defined herein.

1 . A fiber produced by spinning a composition comprising
 (A) a condensation product obtained by condensing one or more kinds of a compound represented by the formula (1), and   (B) an acid compound:   
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is an amino group optionally substituted by an alkoxymethyl group having 2-6 carbon atoms or a hydroxymethyl group, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an aryl group having 6-14 carbon atoms; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms. 
 
     
     
         2 . The fiber according to  claim 1 , wherein the above-mentioned composition further comprises (C) a solvent. 
     
     
         3 . The fiber according to  claim 1 , wherein the above-mentioned R 1  is selected from an amino group optionally substituted by a methoxymethyl group, an ethoxymethyl group, a propoxymethyl group, a butoxymethyl group or a hydroxymethyl group, a vinyl group, a propenyl group, a butenyl group, a phenyl group and a naphthyl group, and
 the above-mentioned R 2 , R 3 , R 4  and R 5  are the same or different and each is selected from a hydrogen atom, a hydroxymethyl group, a methoxymethyl group, an ethoxymethyl group, a propoxymethyl group, a butoxymethyl group, a vinyl group, a propenyl group, a butenyl group, a methyl group, an ethyl group, a propyl group and a butyl group.   
     
     
         4 . The fiber according to  claim 1 , wherein
 (A) the condensation product is a condensation product obtained by condensing a compound represented by the formula (1A):   
       
         
           
           
               
               
           
         
       
       wherein
 R 1A  is an amino group optionally substituted by an alkoxymethyl group having 2-6 carbon atoms or a hydroxymethyl group; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms, and/or 
 a compound represented by the formula (1B): 
 
       
         
           
           
               
               
           
         
       
       wherein
 R 1B  is an aryl group having 6-14 carbon atoms; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms. 
 
     
     
         5 . The fiber according to  claim 1 , wherein
 (A) the condensation product has a weight average molecular weight of 1,000-1,000,000.   
     
     
         6 . The fiber according to  claim 1 , wherein the above-mentioned spinning is electrospinning. 
     
     
         7 . The fiber according to  claim 1 , which is a nanofiber and/or a microfiber. 
     
     
         8 . A composition for producing a fiber, comprising
 (A) a condensation product obtained by condensing one or more kinds of a compound represented by the formula (1), and   (B) an acid compound:   
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is an amino group optionally substituted by an alkoxymethyl group having 2-6 carbon atoms or a hydroxymethyl group, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an aryl group having 6-14 carbon atoms; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms. 
 
     
     
         9 . The composition according to  claim 8 , further comprising (C) a solvent. 
     
     
         10 . The composition according to  claim 8 , wherein
 (A) the condensation product is a condensation product obtained by condensing a compound represented by the formula (1A):   
       
         
           
           
               
               
           
         
       
       wherein
 R 1A  is an amino group optionally substituted by an alkoxymethyl group having 2-6 carbon atoms or a hydroxymethyl group; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms, and/or 
 a compound represented by the formula (1B): 
 
       
         
           
           
               
               
           
         
       
       wherein
 R 1B  is an aryl group having 6-14 carbon atoms; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms. 
 
     
     
         11 . The composition according to  claim 8 , wherein
 (A) the condensation product has a weight average molecular weight of 1,000-1,000,000.   
     
     
         12 . The composition according to  claim 8 , wherein
 (A) the condensation product has a solid content of 1-90 wt %.   
     
     
         13 . A production method of a fiber, comprising
 (first step) a step of obtaining (A) a condensation product solution by condensing a monomer composition containing one or more kinds of a compound represented by the formula (1),   (second step) a step of obtaining a composition for producing a fiber by adding (B) an acid compound and (C) a solvent to the aforementioned (A) the condensation product solution, and   (third step) a step of spinning the aforementioned composition for producing a fiber:   
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is an amino group optionally substituted by an alkoxymethyl group having 2-6 carbon atoms or a hydroxymethyl group, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an aryl group having 6-14 carbon atoms; and 
 R 2 , R 3 , R 4  and R 5  are the same or different and each is a hydrogen atom, a hydroxymethyl group, an alkoxymethyl group having 2-6 carbon atoms, an alkenyl group having 2-6 carbon atoms or an alkyl group having 1-6 carbon atoms. 
 
     
     
         14 . The method according to  claim 13 , further comprising a step of heating the spun fiber at 50-300° C. 
     
     
         15 . The method according to  claim 13 , wherein the above-mentioned spinning is electrospinning. 
     
     
         16 . A biocompatible material comprising the fiber according to  claim 1 .