Antimicrobial compositions and method of use

Abstract

Disclosed herein are antimicrobial compositions, kits, and articles of manufacture. Further disclosed herein are methods for treating surfaces, including tissue, inter alia, wounds, with the disclosed compositions.

What is claimed is: 
     
         1 . An aqueous antimicrobial composition, comprising the following compounds:
 i)   
       
         
           
           
               
               
           
         
         ii) 
       
       
         
           
           
               
               
           
         
         iii) 
       
       
         
           
           
               
               
           
         
       
       and
 iv) 
 
       
         
           
           
               
               
           
         
         wherein the composition has a pH of from about 3 to about 8. 
       
     
     
         2 . The composition according to  claim 1 , further comprising a source of hydrogen peroxide. 
     
     
         3 . The composition according to  claim 2 , wherein the source of hydrogen peroxide is hydrogen peroxide. 
     
     
         4 . The composition according to  claim 3 , wherein the concentration of hydrogen peroxide is from about 0.5 mM to about 10 mM. 
     
     
         5 . The composition according to  claim 2 , wherein the source of hydrogen peroxide is a saturated or unsaturated, C 2 -C 18  linear, C 3 -C 18  branched or C 3 -C 18  cyclic alkyl peroxyacid having the formula:
   R 100 CO 3 H   wherein R 100  is a hydrocarbon moiety having from about 1 to 17 carbon atoms and R 100  can be substituted in the chain by —OH, —CO 2 H, or the chain can comprise one or more heteroatoms.   
     
     
         6 . The composition according to  claim 5 , wherein the concentration of peroxyacid is from about 0.5 mM to about 10 mM. 
     
     
         7 . The composition according to  claim 1 , wherein the concentration of the compounds (i)-(iv) together is from about 15 mM to about 30 mM. 
     
     
         8 . The composition according to  claim 1 , further comprising a stabilizing system. 
     
     
         9 . The composition according to  claim 1 , further comprising a buffer system. 
     
     
         10 . An antimicrobial composition, comprising
 a) two or more of the following compounds:
 i) 
   
       
         
           
           
               
               
           
         
         
           ii) 
         
       
       
         
           
           
               
               
           
         
         
           iii) 
         
       
       
         
           
           
               
               
           
         
         
           iv) 
         
       
       
         
           
           
               
               
           
         
         
           v) 
         
       
       
         
           
           
               
               
           
         
         b) a source of hydrogen peroxide; and 
         c) the balance water; 
         wherein the composition has a pH of from about 3 to about 8. 
       
     
     
         11 . The composition according to  claim 10 , further comprising a source of hydrogen peroxide. 
     
     
         12 . The composition according to  claim 11 , wherein the source of hydrogen peroxide is hydrogen peroxide. 
     
     
         13 . The composition according to  claim 12 , wherein the concentration of hydrogen peroxide is from about 0.5 mM to about 10 mM. 
     
     
         14 . The composition according to  claim 11 , wherein the source of hydrogen peroxide is a saturated or unsaturated, C 2 -C 18  linear, C 3 -C 18  branched or C 3 -C 18  cyclic alkyl peroxyacid having the formula:
   R 100 CO 3 H   wherein R 100  is a hydrocarbon moiety having from about 1 to 17 carbon atoms and R 100  can be substituted in the chain by —OH, —CO 2 H, or the chain can comprise one or more heteroatoms.   
     
     
         15 . The composition according to  claim 14 , wherein the concentration of peroxyacid is from about 0.5 mM to about 10 mM. 
     
     
         16 . The composition according to  claim 10 , wherein the concentration of the compounds (i)-(iv) together is from about 15 mM to about 30 mM. 
     
     
         17 . The composition according to  claim 10 , further comprising a stabilizing system. 
     
     
         18 . The composition according to  claim 10 , further comprising a buffer system. 
     
     
         19 . A method for disinfecting a surface, comprising contacting a surface in need of disinfection with a composition according to  claim 1 . 
     
     
         20 . A method for disinfecting a surface, comprising contacting a surface in need of disinfection with a composition according to  claim 10 .