Method for inhibiting cellular activation by insulin-like growth factor-1

Abstract

A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or other disease) comprises administering an antagonist that inhibits the binding of IAP to SHPS-1 to the subject in an amount effective to inhibit cellular activation by IGF-1. Compounds and compositions for carrying out such methods are also described.

1 - 20 . (canceled) 
     
     
         21 . A method of producing a protein comprising a porcine IAP linked to a C-terminal FLAG epitope, the method comprising amplifying a porcine IAP gene using a first amplification primer comprising SEQ ID NO: 1 and a second amplification primer comprising SEQ ID NO: 2; cloning the amplification product into an expression vector; and expressing the product of the amplification product from a host cell.