Endoprostheses

Abstract

Endoprostheses are disclosed.

1 - 37 . (canceled) 
     
     
         38 . A method of treating a cavity or lumen in a mammal, the method comprising:
 implanting, into the lumen or cavity of the mammal, an endoprosthesis comprising a tubular member having a coating, the coating comprising a therapeutic agent and a polymeric material including a reaction product of a polyol, an isocyanate and a silsesquioxane having at least two pendant hydroxyl groups, wherein the coating is configured to release substantially all of the therapeutic agent in less than about 200 days at body temperature.   
     
     
         39 . The method of  claim 38 , wherein the therapeutic agent includes an anesthetic agent. 
     
     
         40 . The method of  claim 38 , wherein the therapeutic agent inhibits encrustation of the endoprosthesis. 
     
     
         41 . The method of  claim 38 , wherein the lumen is a ureteral lumen. 
     
     
         42 . The method of  claim 38 , wherein the endoprosthesis is self-expanding. 
     
     
         43 . The method of  claim 38 , wherein the endoprosthesis is formed from a metallic material. 
     
     
         44 . The method of  claim 38 , wherein the endoprosthesis is formed from a polymeric material. 
     
     
         45 . The method of  claim 38 , wherein the coating includes between about 1 percent by weight and about 35 percent by weight of the therapeutic agent. 
     
     
         46 . A method of treating a cavity or lumen in a mammal, the method comprising:
 implanting, into the lumen or cavity of the mammal, an endoprosthesis comprising a tubular member formed at least in part from polymeric material including a reaction product of a polyol, an isocyanate and a silsesquioxane having at least two pendant hydroxyl groups, and a therapeutic agent dispersed within said polymeric material.   
     
     
         47 . The method of  claim 46 , wherein the therapeutic agent includes an anesthetic agent. 
     
     
         48 . The method of  claim 46 , wherein the therapeutic agent inhibits encrustation of the endoprosthesis. 
     
     
         49 . The method of  claim 46 , wherein the lumen is a ureteral lumen. 
     
     
         50 . The method of  claim 38 , wherein the coating is configured to release substantially all of the therapeutic agent in less than about 100 days at body temperature. 
     
     
         51 . The method of  claim 46 , wherein the polymeric material includes between about 1 percent by weight and about 35 percent by weight of the therapeutic agent. 
     
     
         52 . A method of treating a cavity or lumen in a mammal, the method comprising:
 implanting, into the lumen or cavity of the mammal, an endoprosthesis comprising a tubular member formed at least in part from a polymeric material including a reaction product of a polyol, an isocyanate and a silsesquioxane having at least two pendant hydroxyl groups, and a therapeutic agent dispersed within said polymeric material, wherein the polymeric material is configured to release substantially all of the therapeutic agent in less than about 200 days at body temperature.   
     
     
         53 . The method of  claim 52 , wherein the therapeutic agent includes an anesthetic agent. 
     
     
         54 . The method of  claim 52 , wherein the therapeutic agent inhibits encrustation of the endoprosthesis. 
     
     
         55 . The method of  claim 52 , wherein the lumen is a ureteral lumen. 
     
     
         56 . The method of  claim 52 , wherein the coating is configured to release substantially all of the therapeutic agent in less than about 100 days at body temperature. 
     
     
         57 . The method of  claim 52 , wherein the polymeric material includes between about 1 percent by weight and about 35 percent by weight of the therapeutic agent.