Succinate dehydrogenase inhibitor containing compositions

Abstract

A composition containing succinate dehydrogenase inhibitor and a potentiator has been discovered to enhance the activity of the succinate dehydrogenase such that the amount of the succinate dehydrogenase inhibitor need to effectively treat a microbial substance can be reduced substantially. The compositions may be used as additives for paints and coatings, and protecting crops, seeds, wallboard, metal working fluids, wood from mold, fungi and other microbes.

1 . A composition comprising a succinate dehydrogenase inhibitor and an effective amount of a potentiator. 
     
     
         2 . The composition according to  claim 1 , wherein the succinate dehydrogenase inhibitor comprises a carboxamide compound. 
     
     
         3 . The composition according to  claim 2 , wherein the carboxamide compound comprises a compound selected from the group consisting of benalaxyl, benalaxyl-M, benodanil, bixafen, boscalid, carboxin, fenfuram, fenhexamid, flutolanil, fluxapyroxad, furametpyr, isopyrazam, isotianil, kiralaxyl, mepronil, metalaxyl, metalaxyl-M (mefenoxam), ofurace, oxadixyl, oxy-carboxin, penflufen, penthiopyrad, sedaxane, tecloftalam, thifluzamide, tiadinil, 2-amino-4-methyl-thiazole-5-carboxanilide, N-(4′-trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamide and N-(2-(1 ,3,3-trimethyl-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide; dimethomorph, flumorph, pyrimorph, flumetover, fluopicolide, fluopyram, zoxamide; carpropamid, dicyclomet, mandiproamid, oxytetracyclin, silthiofam, N-(6-methoxy-pyridin-3-yl)cyclopropanecarboxylic acid amide, niacinamide and mixtures thereof. 
     
     
         4 . The composition according to  claim 3 , wherein the carboxamide comprises penflufen. 
     
     
         5 . The composition according to  claim 1 , wherein the potentiator is a chelators, organic acids and esters thereof, amines, amine oxides, ammonium carboxylates, aldehydes, efflux pump inhibitors, other enzyme inhibitors, betaines, amides, antioxidants, natural compounds, sulfonamides (respiration inhibitors), or a mixture thereof. 
     
     
         6 . The composition according to  claim 1 , wherein the potentiator comprises one or more compounds selected form from the group consisting of glycolic acid, salicylic acid, citric acid, 3,4-dihydroxyphenylacetic acid (DOPAC), 4,5-dihydroxy-1,3-benzenedisulfonic acid, diethylenetriaminepentacetic acid (DTPA), N,N′-bis(2-hydroxybenzyl)-ethylenediamine-N,N′diacetic acid (HBED), N,N′-1,2-ethanediylbis-aspartic acid (ethylenediamine disuccinate (EDDS)), 3-hydroxy-2-methyl-4-pyrone (maltol), 1,2-dimethyl-3-hydroxy-4-pyridinone, 8-hydroxyquinoline, phytic acid, N,N-bis(carboxymethyl)-L-glutamic acid (GLDA), salicylaldehyde isonicotinoyl hydrazine (SIR), 1-hydroxyethane 1,1-diphosphonic acid (HEDP), 2-hydroxypyridine-N-oxide, triethylenetetramine, neocuproine, beta-thujaplcin, tropolone, 2,6-pyridinedicarboxlic acid (DPC), lactic acid, tartartic acid, octanoic acid, undecanoic acid, myristylamine, Tomamine d16 (C16 alkyl ether amine), Tomamine d14(C 14  alkyl ether amine), N,N-dimethyldecanamine, N,N-dimethyloctylamine, dimethyloctadecylamine, diisoproanolamine, oleylamine, ethanolamine, trialiphatic substituted amine oxide, N-alkylated cyclic amine oxide, dialkylpiperazine di-N-oxide, alkyldi(hydroxy alkyl)amine oxide, dialkylbenzylamine oxide, fatty amido propyldimethyl amine oxide and diamine oxides or triamine oxides thereof, capyryl glycol, decanediol, cimmamaldehyde, metaldehyde, glutaraldehyde, dodecanamide, phenyl-arginine-b-naphthylamide (PAbN), berberine, reserpine, farnesol, piperine, lysozyme, thymol, hydroxytyrosol, hydroxychavicol, flavonoids, carvacol, tea tree oil, terpinen-4-ol, allyl isothiocyanate, hexenal, phytoshinogosene, sulfanilamide, p-toluenesulfonamide, 4-carboxbenzenesulfonamide, 4-amino-6-chloro-1,3-benzenedisulfonamide, 4-(2-aminoethyl)benzene sulfonamide, tetrakis hydroxymethyl phosphonium sulfate, tributyl tetradecyl phosphonium chloride, and guanidine hydrochloride. 
     
     
         7 . The composition according to  claim 5  wherein the potentiator comprises a sulfonamide compound. 
     
     
         8 . The composition according to  claim 7 , wherein the sulfonamide compound is selected from the group consisting of sulfanilamide, p-toluenesulfonamide, 4-4-carboxbenzenesulfonamide, 4-amino-6-chloro-1,3-benzenedisulfonamide, 4-(2-4-(2-aminoethyl)benzene sulfonamide. 
     
     
         9 . The composition according to  claim 7 , wherein the potentiator further comprises an additional potentiator other than a sulfonamide. 
     
     
         10 . The composition according to  claim 1 , wherein the potentiator is selected from the group consisting of Tris(2-hydroxyethyl)-N-tallowalkyl-1,3-diaminopropane, N,N-Dimethyldodecylamine, 2-hydroxypyridine-N-oxide, cocoamine oxide, Isononoic Acid (Z)-Octa-9-decenylamine, Toluene sulfonamide, Dehydroascorbic acid zinc salt and a mixture thereof. 
     
     
         11 . The composition according to  claim 9 , wherein the additional potentiator comprises a compound selected from the group consisting of Tris(2-hydroxyethyl)-N-tallowalkyl-1,3-diaminopropane, N,N-Dimethyldodecylamine, 2-hydroxypyridine-N-oxide, cocoamine oxide, Isononoic Acid (Z)-Octa-9-decenylamine, Toluene sulfonamide, Dehydroascorbic acid zinc salt and a mixture thereof. 
     
     
         12 . The composition according to  claim 1 , wherein the weight ratio of the succinate dehydrogenase inhibitor to potentiator is about 100:1 to about 1:100. 
     
     
         13 . The composition according to  claim 12 , wherein the weight ratio of the succinate dehydrogenase inhibitor to potentiator is about 50:1 to about 1:50. 
     
     
         14 . The composition according to  claim 13 , wherein the weight ratio of the succinate dehydrogenase inhibitor to potentiator is about 10:1 to about 1:10. 
     
     
         15 . The composition according to  claim 1 , further comprising an additional antimicrobial component. 
     
     
         16 . The composition according to  claim 15 , wherein the addition antimicrobial component comprises at least one component selected from the group consisting of at least one further compound from the group benzimidazoles, imidazoles, morpholine derivatives, copper compounds, pyrethroids, triazoles, sulfonamides, boron compound, pyrithione compounds and mixture thereof. 
     
     
         17 . The composition according to  claim 16 , wherein the additional antimicrobial component comprises zinc pyrithione. 
     
     
         18 . A method of treating wood comprising applying a composition according to  claim 1  to wood. 
     
     
         19 . The treated wood prepared in accordance with the method according to  claim 18 . 
     
     
         20 . A method of protecting crops comprising applying a composition according to  claim 1  to a crop. 
     
     
         21 . A treated crop prepared in accordance with the method according to  claim 20 . 
     
     
         22 . A method of protecting seeds comprising applying a composition according to  claim 1  to a seed. 
     
     
         23 . A treated seed prepared in accordance with the method according to  claim 22 . 
     
     
         24 . A method of treating dandruff in a mammal in need of treatment comprising applying a composition according to  claim 1  to hair of the mammal in need of treatment. 
     
     
         25 . A paint comprising a base component and a composition according to  claim 1 . 
     
     
         26 . A plastic material having antimicrobial properties comprising a base component and a composition according to  claim 1 . 
     
     
         27 . A method of treating wallboard comprising applying a composition according to  claim 1  to wallboard. 
     
     
         28 . The treated wallboard prepared in accordance with the method according to  claim 27 . 
     
     
         29 . A method of treating metal working fluids comprising adding a composition according to  claim 1  to metal working fluid.