Analysis device, analysis method, optical element and electronic apparatus for analysis device and analysis method, and method of designing optical element

Abstract

An analysis device includes an optical element which includes a metal layer, a light transmitting layer on the metal layer, and a plurality of metal particles on the light transmitting layer arranged at a first interval P1 in a first direction and arranged at a second interval P2 in a second direction intersecting the first direction, P1<P2≦Q+P1, a light source which irradiates incident light of linearly polarized light in the first direction onto the optical element, and a detector which detects light emitted from the optical element. Where Q represents the interval between diffraction gratings.

1 . An analysis device comprising:
 an optical element which includes a metal layer, a light transmitting layer provided on the metal layer to transmit light, and a plurality of metal particles arranged on the light transmitting layer at a first interval P1 in a first direction and arranged at a second interval P2 in a second direction intersecting the first direction;   wherein P1<P2≦Q+P1;   wherein Q represents an interval between diffraction gratings given by:
   (ω/ c )·{∈·∈(ω)/(∈+∈(ω))} 1/2 =∈ 1/2 ·(ω)/∈)·sin θ+2 mπ/Q ( m=± 1,±2, . . . ); and
 
   wherein an angular frequency of a localized surface plasmon excited in a metal particle column is ω, a dielectric constant of a metal constituting the metal layer is ∈(ω), a dielectric constant around the metal layer is ∈, light speed in a vacuum is c, and an irradiation angle of incident light which is an inclination angle of incident light from a thickness direction of the light transmitting layer is θ.   
     
     
         2 . The analysis device according to  claim 1 , wherein 60 nm P2≦1310 nm. 
     
     
         3 . The analysis device according to  claim 1 , wherein 60 nm P2≦660 nm. 
     
     
         4 . The analysis device according to  claim 1 , wherein 60 nm P1≦120 nm. 
     
     
         5 . The analysis device according to  claim 1 , wherein a size of the metal particles in the first direction is D and 30 nm≦D≦72 nm. 
     
     
         6 . The analysis device according to  claim 1 , wherein a size of the metal particles in a height direction is T and 4 nm≦T≦20 nm. 
     
     
         7 . The analysis device according to  claim 1 ,
 wherein the light transmitting layer is a dielectric layer in which a height direction of the metal particles is a thickness direction, and   a thickness of the dielectric layer is G and 20 nm≦G≦60 nm.   
     
     
         8 . The analysis device according to  claim 1 , further comprising a detector which detects light emitted from the optical element, wherein the detector detects Raman scattering light enhanced by the optical element. 
     
     
         9 . The analysis device according to  claim 1 , further comprising a light source which irradiates incident light of linearly polarized light in the first direction onto the optical element, wherein the light source irradiates incident light having a wavelength greater than a size in a height direction and a size in the first direction of the metal particles onto the optical element. 
     
     
         10 . An analysis method comprising:
 providing an optical element;   wherein the optical element includes a metal layer, a light transmitting layer provided on the metal layer to transmit light, and a plurality of metal particles arranged at a first interval P1 in a first direction and arranged at a second interval P2 in a second direction intersecting the first direction on the light transmitting layer,   wherein P1<P2≦Q+P1;   wherein incident light of linearly polarized light in the first direction is irradiated onto the optical element; and   wherein Q represents an interval between diffraction gratings given by:
   (ω/ c )·{∈·∈(ω)/(∈+∈(ω))} 1/2 =∈ 1/2 ·(ω)/∈)·sin θ+2 mπ/Q ( m=± 1,±2, . . . ); and
 
   wherein an angular frequency of a localized surface plasmon excited in a metal particle column is ω, a dielectric constant of a metal constituting the metal layer is ∈(ω), a dielectric constant around the metal layer is ∈, light speed in a vacuum is c, and an irradiation angle of incident light which is an inclination angle of incident light from a thickness direction of the light transmitting layer is θ.   
     
     
         11 . A method of manufacturing an optical element comprising:
 providing a light transmitting layer on a metal layer to transmit light; and   providing a plurality of metal particles on the light transmitting layer arranged at a first interval P1 in a first direction and arranged at a second interval P2 in a second direction intersecting the first direction,   wherein P1<P2≦Q+P1;   wherein Q represents an interval between diffraction gratings given by:
   (ω/ c )·{∈·∈(ω)/(∈+∈(ω))} 1/2 =∈ 1/2 ·(ω)/∈)·sin θ+2 mπ/Q ( m=± 1,±2, . . . ); and
 
   wherein an angular frequency of a localized surface plasmon excited in a metal particle column is ω, a dielectric constant of a metal constituting the metal layer is ∈(ω), a dielectric constant around the metal layer is ∈, light speed in a vacuum is c, and an irradiation angle of incident light which is an inclination angle of incident light from a thickness direction of the light transmitting layer is θ.   
     
     
         12 . A method of manufacturing an optical element comprising:
 providing a light transmitting layer; and   providing a plurality of metal particles on the light transmitting layer arranged at a first interval in a first direction and arranged at a second interval in a second direction intersecting the first direction,   wherein the metal particles are arranged in a matrix in the first and second directions such that a localized surface plasmon and a propagated surface plasmon occur.   
     
     
         13 . An electronic apparatus comprising:
 the analysis device according to  claim 8 ;   a calculation unit which calculates diagnostic information based on detection information from the detector;   a storage unit which stores the diagnostic information; and   a display unit which displays the diagnostic information.   
     
     
         14 . The electronic apparatus according to  claim 13 ,
 wherein the diagnostic information includes information relating to the presence and/or absence or the amount of at least one bio-related material selected from a group consisting of bacteria, viruses, protein, nucleic acids, and antigens and/or antibodies, or at least one compound selected from inorganic molecules and organic molecules.   
     
     
         15 . (canceled)