Biological sensing device and method for separating biomolecule

Abstract

A biological sensing device and a method for separating a biomolecule are provided. The biological sensing device includes an amino acid sequence and a signal-generating unit. The amino acid sequence includes SEQ ID NO: 1 or SEQ ID NO: 2, and is for binding with UlaG protein labeled on a biomolecule. The signal-generating unit connects to the amino acid sequence.

What is claimed is: 
     
         1 . A biological sensing device, comprising:
 an amino acid sequence, comprising SEQ ID NO: 1 or SEQ ID NO: 2, and being for binding with UlaG protein labeled on a biomolecule; and   a signal-generating unit, connecting to the amino acid sequence.   
     
     
         2 . The biological sensing device of  claim 1 , wherein the biomolecule is a protein, a cell, a bacterium, or a combination thereof. 
     
     
         3 . The biological sensing device of  claim 2 , wherein the bacterium is a Gram-positive bacterium. 
     
     
         4 . The biological sensing device of  claim 3 , wherein the Gram-positive bacterium is from the genus  Streptococcus.    
     
     
         5 . The biological sensing device of  claim 4 , wherein the Gram-positive bacterium from the genus  Streptococcus  is  Streptococcus pneumoniae.    
     
     
         6 . The biological sensing device of  claim 1 , wherein the signal-generating unit is a transistor, a fluorescent molecule, or a chip. 
     
     
         7 . A method for separating a biomolecule, comprising:
 providing a sample, the sample comprising a biomolecule having UlaG protein;   contacting the sample with an amino acid sequence comprising SEQ ID NO: 1 or SEQ ID NO: 2;   binding the amino acid sequence with the UlaG protein; and   removing a portion of the sample not bound with the amino acid sequence to separate the biomolecule from the sample.   
     
     
         8 . The method of  claim 7 , further comprising modifying the UlaG protein onto the biomolecule. 
     
     
         9 . The method of  claim 7 , further comprising modifying the sample onto a substrate. 
     
     
         10 . The method of  claim 7 , further comprising connecting the amino acid sequence to a signal-generating unit.