Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms

Abstract

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.

1 - 35 . (canceled) 
     
     
         36 . A method of developing a treatment plan for a subject with a disease or condition responsive to exercise, comprising: determining the sequence of a polynucleotide of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide; and using the sequence to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program; and developing a treatment plan for the subject to treat the disease or condition. 
     
     
         37 . The method of  claim 36 , wherein determining the sequence comprises at least one of sequencing, RFLP analysis, amplification, primer extension, and microarray analysis. 
     
     
         38 . The method of  claim 36 , wherein determining the sequence of the polynucleotide comprises identifying a nucleotide at a base position of the acid ceramidase polynucleotide sequence selected from the group consisting of rs2898458, rs7508, and rs3810.