Composition and method to alleviate joint pain using phospholipids and roe extract

Abstract

A dietary supplement composition and associated method has its composition formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in a person having joint pain. The composition includes astaxanthin, low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) having a molecular weight of 0.5 to 300 kilodaltons (kDa), and a phospholipid rich egg roe extract having phospholipid bound EPA and DHA admixed with seed and/or fish oil having an ALA to LA ratio of 1:1 to 6:1 and in an oral dosage form.

That which is claimed is: 
     
         1 . A method to treat and alleviate symptoms of joint pain in a person having joint pain by administering to a person a therapeutic amount of a dietary supplement composition comprising astaxanthin, low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) having a molecular weight of 0.5 to 300 kilodaltons (kDa), and a phospholipid rich egg roe extract admixed with seed oil having an alpha-linolenic acid (ALA) to linoleic acid (LA) ratio of 1:1 to 6:1 and in an oral dosage form. 
     
     
         2 . The method according to  claim 1 , wherein the phospholipid rich egg roe extract admixed with seed oil contains phospholipid bound EPA and DHA. 
     
     
         3 . The method according to  claim 1 , wherein the low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) comprises pro-inflammatory low molecular weight microbial fermented sodium hyaluronate fragments. 
     
     
         4 . The method according to  claim 1 , wherein the low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) has a molecular weight of 0.5 to 100 kDa. 
     
     
         5 . The method according to  claim 1 , wherein the phospholipid rich egg roe extract admixed with seed oil comprises about 15 to about 60 percent phospholipids. 
     
     
         6 . The method according to  claim 1 , wherein the phospholipid rich egg roe extract admixed with seed oil comprises Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) fatty acids wherein the amount of DHA is at least 50 percent greater than the amount of EPA. 
     
     
         7 . The method according to  claim 1 , wherein the phospholipid rich egg roe extract admixed with seed oil includes triacyglycerides. 
     
     
         8 . The method according to  claim 1 , further comprising an antioxidant. 
     
     
         9 . The method according to  claim 1 , wherein the dietary supplement composition is formulated into a single dosage capsule. 
     
     
         10 . The method according to  claim 1 , further comprising forming the seed oil by supercritical CO2 fluid extracting seed oil from a cracked biomass of  perilla frutescens.    
     
     
         11 . A method to treat and alleviate symptoms of joint pain in a person having joint pain by administering to a person a therapeutic amount of a dietary supplement composition comprising astaxanthin, low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) having a molecular weight of 0.5 to 300 kilodaltons (kDa), and a phospholipid rich egg roe extract admixed with a supercritical CO2 fluid extracted  perilla  seed oil derived from a cracked biomass of  perilla frutescens , the seed oil comprising from 60 to 95 percent w/w of PUFAs and the phospholipid rich egg roe extract admixed with seed oil having an alpha-linolenic acid (ALA) to linoleic acid (LA) ratio of 1:1 to 6:1 and in an oral dosage form. 
     
     
         12 . The method according to  claim 11 , wherein the phospholipid rich egg roe extract admixed with seed oil contains phospholipid bound EPA and DHA. 
     
     
         13 . The method according to  claim 11 , wherein the low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) comprises pro-inflammatory low molecular weight microbial fermented sodium hyaluronate fragments. 
     
     
         14 . The method according to  claim 11 , wherein the low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) has a molecular weight of 0.5 to 100 kDa. 
     
     
         15 . The method according to  claim 11 , wherein the phospholipid rich egg roe extract admixed with seed oil comprises about 15 to about 60 percent phospholipids. 
     
     
         16 . The method according to  claim 11 , wherein the phospholipid rich egg roe extract admixed with seed oil comprises Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) fatty acids wherein the amount of DHA is at least 50 percent greater than the amount of EPA. 
     
     
         17 . The method according to  claim 11 , wherein the phospholipid rich egg roe extract admixed with seed oil includes triacyglycerides. 
     
     
         18 . The method according to  claim 11 , further comprising an antioxidant. 
     
     
         19 . The method according to  claim 11 , wherein the dietary supplement composition is formulated into a single dosage capsule. 
     
     
         20 . The method according to  claim 11 , further comprising forming the seed oil by supercritical CO2 fluid extracting seed oil from a cracked biomass of  perilla frutescens , the  perilla  seed oil comprising from 60 to 95 percent w/w of PUFAs in a ratio from 4:1 to 6:1 alpha-linolenic acid (ALA) to linoleic acid (LA).