Compositions and methods for altering human cutaneous microbiome to increase growth of staphylococcus epidermidis and reduce staphylococcus aureus proliferation

Abstract

An antibacterial composition comprising arginine bicarbonate, zinc carbonate, preferably arginine bicarbonate and zinc carbonate (ABZC), in combination, plus one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras, generally to inhibit the growth of pathogenic Staphylococcus aureus bacteria by promoting the growth of non-pathogenic Staphylococcus epidermidis bacteria.

1 . An antibacterial composition, comprising:
 a. arginine, or a salt thereof;   b. a zinc salt;   c. optionally, a buffer sufficient to maintain the pH of said composition at 6.0 or greater upon topical application; and   d. a physiologically-acceptable carrier suitable for topical application, said composition being capable of inhibiting the growth and/or metabolism of  Staphylococcus aureus  to a greater extent than the growth and/or metabolism of  Staphylococcus epidermidis.      
     
     
         2 . The composition of  claim 1 , further comprising phenylalanine. 
     
     
         3 . The composition of  claim 1 , said composition being capable of inhibiting the growth and/or metabolism of malodor-generating microbiota present in the cutaneous regions of a subpart of the human body. 
     
     
         4 . The composition of  claim 3 , wherein said cutaneous regions comprise the axilla, foot-webs and nasal atrium. 
     
     
         5 . The composition of  claim 1 , wherein said zinc salt is selected from zinc carbonate and zinc bicarbonate. 
     
     
         6 . The composition of  claim 1 , wherein said arginine, or a salt thereof is selected from arginine, arginine carbonate and arginine bicarbonate. 
     
     
         7 . The composition of  claim 1 , wherein said zinc salt is zinc carbonate and said arginine salt is arginine bicarbonate. 
     
     
         8 . The composition of  claim 1 , wherein said composition is provided as a topical formulation selected from the group selected from soap, spray, drop, aerosol, powder, roll-on, lotion, cream, stick, solution, sachet, colloidal suspension, film, patch and ointment. 
     
     
         9 . (canceled)