Device and method for delivery of a medicament

Abstract

The disclosure relates to a method of enhancing nicotine or other medicament concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine or other medicaments for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and/or harm reduction. The disclosure further relates various devices and device design principles for practicing these methods.

1 - 48 . (canceled) 
     
     
         49 . A method for delivering a medicament to a user, the method comprising:
 passing a gaseous stream over a first substance to create a first vapor- containing gaseous stream;   passing the first vapor-containing gaseous stream over a second substance to create particles in the gaseous stream; and   delivering the gaseous stream containing the particles to a user.   
     
     
         50 . The method according to  claim 49 , wherein the passing a gaseous stream over a first substance step comprises capturing a vapor of the first substance in the gaseous stream. 
     
     
         51 . The method according to  claim 49 , wherein the step of creating particles comprises contacting a vapor of the second substance with the first vapor-containing gaseous stream. 
     
     
         52 . The method according to  claim 49 , wherein the method steps occur at a temperature of 100 degrees Celsius or less. 
     
     
         53 . The method according to  claim 49 , wherein the step of creating the particles comprises an interaction between the first and second substances. 
     
     
         54 . The method according to  claim 53 , wherein the interaction comprises an acid-base reaction. 
     
     
         55 . The method according to  claim 49 , wherein the first and second substances are volatile substances. 
     
     
         56 . The method according to  claim 49 , wherein one of the first substance and the second substance comprises nicotine. 
     
     
         57 . The method according to  claim 56 , wherein the nicotine comprises free base nicotine. 
     
     
         58 . The method according to  claim 49 , wherein the particles comprise nicotine-containing particles. 
     
     
         59 . The method according to  claim 49 , wherein the particles comprise nicotine salt particles. 
     
     
         60 . The method according to  claim 49 , wherein the particles comprise nicotine pyruvate. 
     
     
         61 . The method according to  claim 49 , wherein at least some of the particles are visible particles. 
     
     
         62 . The method according to  claim 49 , wherein the particles are less than 6 microns in diameter. 
     
     
         63 . The method according to  claim 49 , wherein at least some of the particles are between 0.5 and 5 microns in diameter. 
     
     
         64 . The method according to  claim 49 , wherein the second substrate comprises nicotine. 
     
     
         65 . The method according to  claim 64 , wherein the first substance comprises an organic acid. 
     
     
         66 . The method according to  claim 64 , wherein the first substance comprises pyruvic acid. 
     
     
         67 . The method according to  claim 64 , wherein the nicotine comprises free base nicotine. 
     
     
         68 . The method according to  claim 66 , wherein the method steps occur at a temperature of 40±5 degrees Celsius.