Agent for use in the case of fructose intolerance

Abstract

There is provided a method for treating or reducing the effects of fructose intolerance and health problems associated with excessive fructose intake by administration of glucose isomerase. Other embodiments are also disclosed.

1 - 97 . (canceled) 
     
     
         98 . A method of treating fructose intolerance or reducing the effects of fructose intolerance, the method comprising administering to a subject in need of such treatment or reduction a glucose isomerase, wherein said glucose isomerase is not administered in combination with 5-D-fructose-dehydrogenase. 
     
     
         99 . A method of reducing in a subject at least one of (a) the bioavailability of fructose in the body of said subject, (b) the amount of fructose available to the body of said subject and (c) the amount of fructose available to intestinal bacteria colonizing in the intestine of said subject, the subject being a person who would benefit from such reducing, the method comprising administering to the subject an amount of a glucose isomerase sufficient to effect such reducing in said subject, wherein said glucose isomerase is not administered in combination with 5-D-fructose-dehydrogenase. 
     
     
         100 . The method of  claim 98 , wherein said subject suffers from fructose intolerance. 
     
     
         101 . The method of  claim 100 , wherein said subject suffers from intestinal fructose intolerance. 
     
     
         102 . The method of  claim 101 , wherein said intestinal fructose intolerance is caused by a disorder of fructose absorption. 
     
     
         103 . The method of  claim 98 , wherein the administration occurs after the intake by said subject of fructose or a substance or foodstuff containing fructose in pure form or from which fructose can be released in the digestive tract. 
     
     
         104 . The method of  claim 98 , wherein said glucose isomerase is contained in a pharmaceutical composition or a foodstuff. 
     
     
         105 . The method of  claim 104 , wherein said glucose isomerase is contained in a pharmaceutical composition. 
     
     
         106 . The method of  claim 104 , wherein said glucose isomerase is contained in a foodstuff. 
     
     
         107 . The method of  claim 106 , wherein the foodstuff is selected from the group consisting of (a) foodstuffs for particular nutritional uses; (b) foods for special medical purposes; (c) medical foods; (d) food supplements; (e) dietary supplements; (f) dietetic food supplements; (g) health foods; (h) nutraceuticals; and (i) food additives. 
     
     
         108 . The method of  claim 107 , wherein the foodstuff is a dietary supplement. 
     
     
         109 . The method of  claim 98 , wherein said glucose isomerase is administered orally. 
     
     
         110 . The method of  claim 109 , wherein the glucose isomerase is administered prior to said subject's eating, concurrently with said subject's eating or after said subject's eating. 
     
     
         111 . The method of  claim 109 , wherein the glucose isomerase is formulated in a form selected from the group consisting of (a) coated or non-coated capsules (b) coated or non-coated tablets (c) capsules containing coated or non-coated pellets, granules, or micro- or mini-tablets (d) tablets pressed from coated or non-coated pellets, dragees, or micro- or mini-tablets (e) gel caps (f) a solution, (g) drops, (h) a suspension (i) a gel and (j) a powder. 
     
     
         112 . The method of  claim 111 , wherein the coating of the capsules, tablets, pellets, granules, micro- or mini-tablets and dragees is selected from the group consisting of cellulose acetate phthalate, cellulose derivatives, shellac, polyvinylpyrrolidone derivatives, acrylic acid, polyacrylic acid derivatives and polymethyl methacrylate. 
     
     
         113 . The method of  claim 98 , wherein said glucose isomerase is administered with at least one metal ion. 
     
     
         114 . The method of  claim 98 , wherein the glucose isomerase is a xylose isomerase. 
     
     
         115 . The method of  claim 98 , wherein said glucose isomerase is administered with a second enzyme which cleaves fructose from a sugar which is more complex than fructose. 
     
     
         116 . The method of  claim 115 , wherein said second enzyme is selected from the group consisting of invertase, maltase and combinations thereof. 
     
     
         117 . A method of treating a subject having a condition that is (i) caused by the intake of fructose or fructose containing foodstuffs, or (ii) due to the release of fructose in the digestive tract from other substances, wherein said condition can be treated or ameliorated by the conversion of fructose to glucose in the gastrointestinal tract of said subject by a glucose isomerase, the method comprising administering to said subject in need of such treatment a glucose isomerase, wherein said glucose isomerase is not administered in combination with a 5-D-fructose-dehydrogenase.