Ketorolac tromethamine compositions for treating or preventing ocular pain

Abstract

Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein.

What is claimed is: 
     
         1 . A method of treating ocular pain in a patient, wherein the method comprises the administration of an ophthalmic composition comprising about 0.4% w/v ketorolac tromethamine to an eye of the patient; and wherein the administration results in little or no burning or stinging in the eye of the patient upon topical instillation of the composition. 
     
     
         2 . The method of  claim 1 , wherein the composition is administered one to four times daily. 
     
     
         3 . The method of  claim 1 , wherein the composition is administered four times daily. 
     
     
         4 . The method of  claim 1 , wherein the person is experiencing ocular pain due to corneal refractive surgery. 
     
     
         5 . The method of  claim 1  wherein the composition comprises 0.4% ketorolac tromethamine and about 0.006% benzalkonium chloride. 
     
     
         6 . The method of  claim 1  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride and about 0.015% w/v edetate disodium. 
     
     
         7 . The method of  claim 1  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium and about 0.003% w/v octoxynol 40. 
     
     
         8 . The method of  claim 1  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium, about 0.003% w/v octoxynol 40 and water. 
     
     
         9 . The method of  claim 1  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium, about 0.003% w/v octoxynol 40, water and hydrochloric acid and sodium hydroxide to adjust the pH to about 7.4. 
     
     
         10 . The method of  claim 1 , wherein about one drop QID of the composition is administered to the eye of the patient. 
     
     
         11 . A method of enhancing comfort in a patient suffering from ocular pain, wherein the method comprises the administration of an ophthalmic composition comprising about 0.4% w/v ketorolac tromethamine to an eye of the patient; and wherein the administration results in little or no burning or stinging in the eye of the patient upon topical instillation of the composition. 
     
     
         12 . The method of  claim 11 , wherein the composition is administered four times daily. 
     
     
         13 . The method of  claim 11 , wherein the person is experiencing ocular pain due to corneal refractive surgery. 
     
     
         14 . The method of  claim 11  wherein the composition comprises 0.4% ketorolac tromethamine and about 0.006% benzalkonium chloride. 
     
     
         15 . The method of  claim 11  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride and about 0.015% w/v edetate disodium. 
     
     
         16 . The method of  claim 11  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium and about 0.003% w/v octoxynol 40. 
     
     
         17 . The method of  claim 11  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium, about 0.003% w/v octoxynol 40 and water. 
     
     
         18 . The method of  claim 11  wherein the composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium, about 0.003% w/v octoxynol 40, water and hydrochloric acid and sodium hydroxide to adjust the pH to about 7.4. 
     
     
         19 . The method of  claim 11 , wherein about one drop QID of the composition is administered to the eye of the patient.