Topical dapsone and dapsone/adaplene compositions and methods for use thereof

Abstract

Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include dapsone and/or adapalene in a polymeric viscosity builder. Subject compositions can be adjusted to optimize the dermal delivery profile of dapsone to effectively treat dermatological conditions and improve the efficiency of pharmaceutical products applied to the skin. Use of the polymeric viscosity builder provides compositions with increased concentrations of diethylene glycol monoethyl ether relative to compositions without the polymeric viscosity builder.

What is claimed is: 
     
         1 . A topical pharmaceutical composition comprising:
 about 5% w/w to about 10% w/w dapsone;   about 0.1% w/w to about 0.3% adapalene;   about 30% w/w to about 40% w/w diethylene glycol monoethyl ether;   about 2% w/w to about 6% w/w of a polymeric viscosity builder comprising acrylamide/sodium acryloyldimethyl taurate copolymer; and water.   
     
     
         2 . The composition of  claim 1 , wherein the dapsone is present at a concentration of about 10% w/w. 
     
     
         3 . The composition of  claim 2 , wherein the adapalene is present at a concentration of about 0.1% w/w. 
     
     
         4 . The composition of  claim 3 , wherein the diethylene glycol monoethyl ether is present at a concentration of about 35% w/w. 
     
     
         5 . The composition of  claim 3 , wherein the diethylene glycol monoethyl ether is present at a concentration of about 40% w/w. 
     
     
         6 . The composition of  claim 1 , wherein the polymeric viscosity builder is present at a concentration of about 4% w/w. 
     
     
         7 . The composition of  claim 1 , wherein the topical pharmaceutical composition further comprises methyl paraben. 
     
     
         8 . The composition of  claim 1 , wherein the topical pharmaceutical composition further comprises EDTA.