Hypertonic antimicrobial therapeutic compositions

Abstract

Therapeutic compositions, primarily for topical application, and methods of making and using the composition. Pharmaceutical compositions formulated for specific forms of administration are also provided.

What is claimed is: 
     
         1 - 12 . (canceled) 
     
     
         13 . A therapeutic composition comprising:
 a) a chloride salt;   b) a source of bicarbonate; and   c) a source of hypochlorite;   wherein the amount of the salt in the composition is sufficient to render the composition hypertonic; and, wherein the composition is alkaline.   
     
     
         14 . The composition of  claim 13 , wherein
 the concentration of the chloride salt in the composition is at least 200 mM;   the concentration of the source of bicarbonate in the composition is at least 4.9M;   the concentration of the source of hypochlorite is at least 0.5% (w/w).   
     
     
         15 . The therapeutic composition of  claim 13 , wherein the concentration of salt in the composition is in the range of from about 4M to about 8M. 
     
     
         16 . The composition of  claim 13 , wherein the chloride salt is selected from the group consisting of sodium chloride and potassium chloride. 
     
     
         17 . The composition of  claim 13 , wherein the source of bicarbonate is selected from the group consisting of sodium bicarbonate, calcium bicarbonate, ammonium bicarbonate and sodium percarbonate. 
     
     
         18 . The composition of  claim 13 , wherein the source of hypochlorite is N-chloro-tosylamide. 
     
     
         19 . The composition of  claim 13 , further comprising an antimicrobial agent. 
     
     
         20 . The composition of  claim 19 , wherein the antimicrobial agent is selected from the group consisting of biguanides, bisbiguanides, triguanides, and analogues thereof. 
     
     
         21 . The composition of  claim 19 , wherein the antimicrobial agent is chlorhexidine. 
     
     
         22 . The therapeutic composition of  claim 13 , wherein the composition further comprises at least one compound selected from the group consisting of an oxygen-producing compound, a poloxamer, a surfactant and a polyhydroxy acid. 
     
     
         23 . The therapeutic composition of  claim 22 , wherein
 the concentration of the oxygen-producing compound in the composition is in the range of about 0.1% (v/v) to about 1% (v/v);   the concentration of poloxamer in the composition is at least 4% (w/w);   the concentration of surfactant in the composition is at least about 0.1% (w/w);   the concentration of polyhydroxy acid in the composition is at least about 0.2% (w/w); or, the concentration of surfactant in the composition is at least 0.1% (w/w).   
     
     
         24 . The composition of  claim 13 , wherein the pH of the composition is in the range of about 7.2 to about 9.5. 
     
     
         25 . The therapeutic composition of  claim 13 , further comprising at least one compound selected from the group consisting of chlorhexidine, polaxmer 237, lauramine oxide, and gluconolactone;
 wherein the chlorine salt is selected sodium chloride or potassium chloride;   wherein the source of carbonate is selected from the group consisting of sodium bicarbonate, potassium bicarbonate, calcium bicarbonate and ammonium bicarbonate;   wherein the source of hypochlorite is N-chlorotosylamide; and,   wherein the pH of the composition is in the range of about 7.2 to about 9.5   
     
     
         26 . A method of treating a patient having a wound, an infection, inflammation of that is experiencing pain, comprising administering to the patient a therapeutic composition comprising:
 a) a chloride salt;   b) a source of bicarbonate; and   c) a source of hypochlorite;
 wherein the amount of the salt in the composition is sufficient to render the composition hypertonic; and, wherein the composition is alkaline. 
   
     
     
         27 . The method of  claim 26 , wherein said administration potentiates wound healing, reduces the infection, reduces inflammation, promotes angiogenesis, or reduces pain. 
     
     
         28 . The method of  claim 26 , wherein:
 the concentration of the chloride salt in the composition is at least 200 mM;   the concentration of the source of carbonate in the composition is at least 4.9M; and,   the concentration of the source of hypochlorite is at least 0.5% (w/w).   
     
     
         29 . The method of  claim 26 , wherein the therapeutic composition further comprises at least one compound selected from the group consisting of an oxygen-producing compound, a poloxamer, a surfactant and a polyhydroxy acid. 
     
     
         30 . A medical device comprising a therapeutic composition comprising:
 a) a chloride salt;   b) a source of bicarbonate; and   c) a source of hypochlorite;   wherein the amount of the salt in the composition is sufficient to render the composition hypertonic; and, wherein the composition is alkaline.   
     
     
         31 . The medical device of  claim 30 , wherein the device comprises a bandage, a dressing, a patch, a suture, a collagen plug, a catheter or a surgical implant, 
     
     
         32 . The method of  claim 30 , wherein:
 the concentration of the chloride salt in the composition is at least 200 mM;   the concentration of the source of carbonate in the composition is at least 4.9M; and,   the concentration of the source of hypochlorite is at least 0.5% (w/w).