Systems and methods for diagnosis, risk assessment, and/or virtual treatment assessment of visceral ischemia

Abstract

Systems and methods are disclosed for diagnosis, risk assessment, and/or virtual treatment assessment of visceral ischemia and related disorders. One method includes receiving a patient-specific anatomic model of a patient's visceral vasculature, including visceral vasculature of the patient's visceral organs and bowel; determining a location in the patient-specific anatomic model of the patient's visceral vasculature; determining, for the location in the patient-specific anatomic model, a blood flow characteristic of blood flow through the location in the patient-specific anatomic model of the patient's visceral vasculature; determining a tissue region of the patient's bowel proximate the location in the patient-specific anatomic model of the patient's visceral vasculature; and generating an assessment of blood supply adequacy to the tissue region of the patient's bowel or generating a risk score for risk of disease for the patient's bowel, based on the determined blood flow characteristic and an expected blood flow characteristic associated with the tissue region of the patient's bowel.

1 - 20 . (canceled) 
     
     
         21 . A computer-implemented method of assessment of visceral ischemia and related disorders, the method comprising:
 receiving a first physiological state of a patient;   determining, based on the first physiological state of the patient, a first blood flow characteristic of the patient's visceral organs and bowel;   receiving a second physiological state of the patient, the second physiological state being different from the first physiological state;   determining, based on the second physiological state of the patient, a second blood flow characteristic of the patient's visceral organs and bowel;   creating a visual display comparing the first blood flow characteristic and the second blood flow characteristic, the visual display including a table, a chart, or a representation of the patient's visceral vasculature or bowel.   
     
     
         22 . The computer-implemented method of  claim 21 , wherein the blood flow characteristic includes one or more of blood pressure, flow rate, fractional flow reserve, or portal venous pressure. 
     
     
         23 . The computer-implemented method of  claim 21 , further comprising:
 determining the first blood flow characteristic or the second blood flow characteristic using a fluid simulation or blood flow characteristics associated with one or more other patients.   
     
     
         24 . The computer-implemented method of  claim 21 , further including:
 generating an assessment of blood supply adequacy defining an adequacy of blood supply to a tissue region of the patient's viscera or bowel, or generating a risk score defining a risk of disease of the patient's viscera or bowel, based on the comparison of the first blood flow characteristic and the second blood flow characteristic.   
     
     
         25 . The computer-implemented method of  claim 24 , further comprising:
 receiving a patient-specific anatomic model including at least a portion of the patient's bowel;   determining blood flow demand based on the portion of the patient's bowel and one or both of the first physiological state or the second physiological state; and   determining the assessment of blood supply adequacy based on the determined blood flow demand and the comparison of the first blood flow characteristic and the second blood flow characteristic.   
     
     
         26 . The computer-implemented method of  claim 24 , further comprising:
 determining the risk score for risk of disease to one or more regions of the patient's viscera or bowel based on the comparison of the first blood flow characteristic and the second blood flow characteristic, wherein the risk of disease may include risk of one or more of mesenteric ischemia, intestinal ischemia, ischemic colitis, abdominal pain, gangrene, bowel perforation, sepsis, stricture, mesenteric ischemia, inflammatory conditions.   
     
     
         27 . The computer-implemented method of  claim 21 , further comprising:
 generating a physical activity intensity level recommendation for the patient, based on the comparison of the first blood flow characteristic and the second blood flow characteristic.   
     
     
         28 . The computer-implemented method of  claim 21 , further comprising:
 receiving a location in the patient's visceral vasculature, wherein the first blood flow characteristic and the second blood flow characteristic are blood flow characteristics at the received location in the patient's visceral vasculature.   
     
     
         29 . A system for assessment of visceral ischemia and related disorders, the system comprising:
 a data storage device storing instructions for assessment of ischemic colitis; and   a processor configured to execute the instructions to perform a method including:
 receiving a first physiological state of a patient; 
 determining, based on the first physiological state of the patient, a first blood flow characteristic of the patient's visceral organs and bowel; 
 receiving a second physiological state of the patient, the second physiological state being different from the first physiological state; 
 determining, based on the second physiological state of the patient, a second blood flow characteristic of the patient's visceral organs and bowel; 
 creating a visual display comparing the first blood flow characteristic and the second blood flow characteristic, the visual display including a table, a chart, or a representation of the patient's visceral vasculature or bowel. 
   
     
     
         30 . The system of  claim 29 , wherein the blood flow characteristic includes one or more of blood pressure, flow rate, fractional flow reserve, or portal venous pressure. 
     
     
         31 . The system of  claim 29 , wherein the system is further configured for:
 determining the first blood flow characteristic or the second blood flow characteristic using a fluid simulation or blood flow characteristics associated with one or more other patients.   
     
     
         32 . The system of  claim 29 , wherein the system is further configured for:
 generating an assessment of blood supply adequacy defining an adequacy of blood supply to a tissue region of the patient's viscera or bowel, or generating a risk score defining a risk of disease of the patient's viscera or bowel, based on the comparison of the first blood flow characteristic and the second blood flow characteristic.   
     
     
         33 . The system of  claim 32 , wherein the system is further configured for:
 receiving a patient-specific anatomic model including at least a portion of the patient's bowel;   determining blood flow demand based on the portion of the patient's bowel and one or both of the first physiological state or the second physiological state; and   determining the assessment of blood supply adequacy based on the determined blood flow demand and the comparison of the first blood flow characteristic and the second blood flow characteristic.   
     
     
         34 . The system of  claim 32 , wherein the system is further configured for:
 determining the risk score for risk of disease to one or more regions of the patient's viscera or bowel based on the comparison of the first blood flow characteristic and the second blood flow characteristic, wherein the risk of disease may include risk of one or more of mesenteric ischemia, intestinal ischemia, ischemic colitis, abdominal pain, gangrene, bowel perforation, sepsis, stricture, mesenteric ischemia, inflammatory conditions.   
     
     
         35 . The system of  claim 29 , wherein the system is further configured for:
 generating a physical activity intensity level recommendation for the patient, based on the comparison of the first blood flow characteristic and the second blood flow characteristic.   
     
     
         36 . The system of  claim 29 , wherein the system is further configured for:
 receiving a location in the patient's visceral vasculature, wherein the first blood flow characteristic and the second blood flow characteristic are blood flow characteristics at the received location in the patient's visceral vasculature.   
     
     
         37 . A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of assessment of visceral ischemia and related disorders, the method comprising:
 receiving a first physiological state of a patient;   determining, based on the first physiological state of the patient, a first blood flow characteristic of the patient's visceral organs and bowel;   receiving a second physiological state of the patient, the second physiological state being different from the first physiological state;   determining, based on the second physiological state of the patient, a second blood flow characteristic of the patient's visceral organs and bowel;   creating a visual display comparing the first blood flow characteristic and the second blood flow characteristic, the visual display including a table, a chart, or a representation of the patient's visceral vasculature or bowel.   
     
     
         38 . The non-transitory computer readable medium of  claim 37 , wherein the blood flow characteristic includes one or more of blood pressure, flow rate, fractional flow reserve, or portal venous pressure. 
     
     
         39 . The non-transitory computer readable medium of  claim 37 , the method further comprising:
 determining the first blood flow characteristic or the second blood flow characteristic using a fluid simulation or blood flow characteristics associated with one or more other patients.   
     
     
         40 . The non-transitory computer readable medium of  claim 37 , the method further comprising:
 generating an assessment of blood supply adequacy defining an adequacy of blood supply to a tissue region of the patient's viscera or bowel, or generating a risk score defining a risk of disease of the patient's viscera or bowel, based on the comparison of the first blood flow characteristic and the second blood flow characteristic.