Hyaluronic acid and its use for treating venous insufficiency and varicose veins

Abstract

The present invention relates to an injectable aqueous viscous solution for treating varicose veins. It also relates to a catheter system with cannulas for vascular puncture with double or triple cut tip comprising, (i) an outer cannula (non-cutting element), a tube-like construction which is slightly flexible, (a) the tip zone being tapered to ease introduction, (b) the edges being optionally rounded to provide atraumatic advancement (c) optionally with a Luer-lock connector (ii) a hollow needle which is flexible and bendable (c) optionally with a transparent flashback chamber, wherein (d) the diameter of the needle is below the diameter of the catheter, wherein (iii) the needle and outer cannula are connected by a temporary lock to ensure the needle tip is fixed in adequate position outside the outer cannula outer cannula during skin puncture and introduction towards the target region.

1 . A composition comprising an injectable viscous aqueous solution with a half-life within human connective tissue of more than 1 week, wherein the viscous aqueous solution is present in the composition in an effective amount for treating venous diseases characterized by dilated veins. 
     
     
         2 . The composition according to  claim 1 , comprising one or more of the following compounds: poly lactic acid, alginate and hyaluronic acid. 
     
     
         3 . The composition according to  claim 1 , comprising about 0.1% to about 3% hyaluronic acid which is optionally cross-linked with 1,4-butanediol diglycidyl ether (BDDE). 
     
     
         5 . The composition according to  claim 2 , wherein the concentration of hyaluronic acid is about 0.25% 2%. 
     
     
         5 . The composition according to  claim 2 , wherein the hyaluronic acid is between 1 million and 8 million Da. 
     
     
         6 . The composition according to  claim 1 , additionally comprising a local anesthetic. 
     
     
         7 . The composition according to  claim 6 , wherein the local anesthetic is selected from the group consisting of scandicain, mepivacaine, cocaine, procaine, benzocaine (ethoform), lidocaine, mepivacain, bupivacaine, ropivacain, etidocain, prilocain and tetracain. 
     
     
         8 . The composition according to  claim 1 , wherein the venous disease is selected from the group of aneurysm, varicose veins, insufficient veins, dilated veins and ectasias. 
     
     
         9 . A catheter system comprising cannulas for vascular puncture with double or triple cut tip comprising:
 i. an outer cannula (non-cutting element), a tube-like construction which is slightly flexible,
 a. the tip zone being tapered to ease introduction, 
 b. the edges being optionally rounded to provide a traumatic advancement, and 
 c. optionally with a Luer-lock connector, 
   ii. a hollow needle which is flexible and bendable
 a. optionally with a transparent flashback chamber, wherein 
 b. the diameter of the needle is below the diameter of the outer part, wherein 
   iii. the needle and outer cannula are connected by a temporary lock to ensure the needle tip is fixed in adequate position outside the outer cannula during skin puncture and introduction towards the target region.   
     
     
         10 . The catheter system according to  claim 9 , wherein the temporary lock is further capable of fixing the needle inside the outer cannula. 
     
     
         11 . A Kit comprising a catheter according to  claim 10  and a composition according to  claim 1 .