Nutritional composition having lipophilic compounds with improved solubility and bioavailability

Abstract

Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.

1 . A nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising:
 an activated assembly comprising at least one hydrophobic protein, at least one combination of monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound,   wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.   
     
     
         2 . The nutritional composition of  claim 1 , wherein the assembly is (i) water soluble; and (ii) has a size of 100 kD to 1000 kD. 
     
     
         3 . The nutritional composition of  claim 1 , wherein MDG increases the concentration of protein of the assembly by at least 2% compared to a nutritional composition without MDG. 
     
     
         4 . The nutritional composition of  claim 1 , wherein MDG increases the bound lipophilic compound of the assembly by at least 2% compared to a nutritional composition without MDG. 
     
     
         5 . (canceled) 
     
     
         6 . The nutritional composition of  claim 1 , wherein the assembly is still water soluble after centrifugation at about 31,000×g for at least 1 hour at 20° C. 
     
     
         7 - 8 . (canceled) 
     
     
         9 . The nutritional composition of  claim 1 , wherein the assembly is stable for at least 12 months at 23° C. 
     
     
         10 - 11 . (canceled) 
     
     
         12 . The nutritional composition of  claim 1 , wherein the hydrophobic protein is β-lactoglobulin, bovine lactoferrin, γ 2 -casein, β-casein, α-lactalbumin, or combinations thereof. 
     
     
         13 . (canceled) 
     
     
         14 . The nutritional composition of  claim 1 , wherein the lipophilic compound is a carotenoid, a lipid soluble vitamin, a lipophilic antioxidant or combinations thereof. 
     
     
         15 . (canceled) 
     
     
         16 . The nutritional composition of  claim 1 , wherein the fat is MDG, coconut oil, fractionated coconut oil, soy oil, corn oil, olive oil, safflower oil, high oleic coconut oil, fractionated coconut oil, soy oil, corn oil, olive oil, safflower oil, high oleic safflower oil, sunflower oil, high oleic sunflower oil, palm oil, palm kernel oil, palm olein, canola oil, marine oils, cottonseed oil, flax seed oil, hemp seed oil, peanut oil, borage oil, algal oils, fungal oils, MCT oil (medium chain triglycerides) and combinations thereof. 
     
     
         17 . The nutritional composition of  claim 1  comprising about 145 mg/kg to about 890 mg/kg of MDG based on total weight of the composition. 
     
     
         18 . (canceled) 
     
     
         19 . The nutritional composition of  claim 1  comprising about 1.0 μg/kg to about 7.0 g/kg of a lipophilic compound based on total weight of the composition. 
     
     
         20 - 21 . (canceled) 
     
     
         22 . The nutritional composition of  claim 1 , wherein the ratio of MDG to lipophilic compound comprises a ratio of about 12000:1 to about 1:1 (w/w). 
     
     
         23 . (canceled) 
     
     
         24 . The nutritional composition of  claim 1  comprising about 1.0 g/L to about 100 g/L of hydrophobic protein based on total weight of the composition. 
     
     
         25 . The nutritional composition of  claim 1  further comprising choline. 
     
     
         26 . (canceled) 
     
     
         27 . The nutritional composition of  claim 1  further comprising lecithin. 
     
     
         28 . (canceled) 
     
     
         29 . The nutritional composition of  claim 1  further comprising docosahexaenoic acid (“DHA”). 
     
     
         30 . (canceled) 
     
     
         31 . The nutritional composition of  claim 1  further comprising high palmitic acid vegetable oil. 
     
     
         32 - 33 . (canceled) 
     
     
         34 . The nutritional composition of  claim 1 , wherein the nutritional composition comprises a carbohydrate. 
     
     
         35 . (canceled) 
     
     
         36 . A nutritional composition comprising at least one protein and vitamin D, having improved bioavailability of vitamin D, wherein the nutritional composition comprises:
 an assembly comprising a combination of monoglycerides and diglycerides (“MDG”) and vitamin D, wherein the vitamin D has improved bioavailability when administered to a subject.   
     
     
         37 - 40 . (canceled) 
     
     
         41 . A nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising:
 an activated assembly comprising at least one hydrophobic protein, at least one combination of monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound,   wherein at least 15% of the total lipophilic compound in the nutritional composition remains in the aqueous phase after centrifugation at 1,000×g for 1 hour at 20° C.