Gel-Based Compositions and Methods of Use

Abstract

Provided herein are a biocompatible gels such as an oral gel composition. Generally, the oral gel composition may comprise a formulation in ozonized water of a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and glycerol to polymerize the polyacrylate. Optionally, the oral gel composition may comprise a sweetener and/or a flavoring agent. The topical gel composition is a similar formulation in ozonized water with a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and hydrogen peroxide to polymerize the polyacrylate. Further provided is a method of using the gel compositions to reduce dental caries.

What is claimed is: 
     
         1 . A biocompatible gel, comprising:
 an oral formulation of a polymerized biopolymer-ozonized water homogenate and a preservative.   
     
     
         2 . The biocompatible gel of  claim 1 , wherein the biopolymer is a cross-linked polyacrylate polymer. 
     
     
         3 . The biocompatible gel of  claim 1 , wherein the preservative is methyl paraben. 
     
     
         4 . The biocompatible gel of  claim 1 , wherein said biopolymer is polymerized with sodium hydroxide, acetic acid and glycerol. 
     
     
         5 . The biocompatible gel of  claim 1 , further comprising a sweetener. 
     
     
         6 . The biocompatible gel of  claim 5 , wherein the sweetener is trichloro-galactosucrose. 
     
     
         7 . The biocompatible gel of  claim 1 , further comprising a flavoring agent. 
     
     
         8 . The biocompatible gel of  claim 7 , wherein the flavoring agent is mint. 
     
     
         9 . The biocompatible gel of  claim 1 , wherein said oral formulation comprises:
 ozonized water;   a cross-linked polyacrylate polymer;   sodium hydroxide;   acetic acid;   glycerol;   a sweetener;   a preservative; and   a flavoring agent.   
     
     
         11 . An oral gel composition, comprising:
 a formulation in ozonized water of cross-linked polyacrylate, trichloro-galactosucrose and methyl paraben, said polyacrylate polymerized in sodium hydroxide, acetic acid and glycerol.   
     
     
         12 . The oral gel composition of  claim 11 , wherein the ozonized water contains less than 20 μg/l of ozone. 
     
     
         13 . The oral gel composition of  claim 11 , wherein the formulation contains per liter of ozonized water about 35 g to about 45 g of the polyacrylate, about 45 g to about 55 g of the trichloro-galactosucrose, about 0.7 g to about 1.3 g of the methyl paraben, about 4.5 ml to about 5.6 ml of the sodium hydroxide, about 2.5 ml to about 3.5 ml of the acetic acid, and about 2.4 ml to about 3.2 ml of the glycerol. 
     
     
         14 . The oral gel composition of  claim 11 , further comprising a mint flavoring agent. 
     
     
         15 . The oral gel composition of  claim 14 , wherein the formulation contains per liter of ozonized water about 4.5 g to about 5.5 g of the mint flavoring agent. 
     
     
         16 . A method for reducing dental caries in a subject, comprising the step of:
 applying an amount of the oral gel composition of  claim 11  to teeth and gums of the subject effective to prevent the formation of biofilms thereon.