US2016199495A1PendingUtilityA1

Polymer Compositions in Biomedical Applications

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Individually held — no corporate assignee on recordPriority: Jan 13, 2014Filed: Jan 12, 2015Published: Jul 14, 2016
Est. expiryJan 13, 2034(~7.5 yrs left)· nominal 20-yr term from priority
Inventors:Alexander Gorkovenko
A61K 38/47A61K 9/7007C12Y 302/01017A61B 6/481A61K 9/1641A61K 47/36A61K 9/146A61K 9/19A61K 47/34
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Claims

Abstract

The present invention relates to compositions useful for biomedical procedures. More specifically the compositions are useful in procedures involving vascular embolization. The compositions are consist of solutions of aqueous-insoluble C2-C3 linked polyethers of 1,6:2,3-dianhydrohexopyranose derivatives in biocompatible solvents.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A biomedically useful composition comprising:
 a solution of an aqueous insoluble C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivative in a biocompatible solvent.   
     
     
         2 . A composition of  claim 1  wherein the aqueous insoluble C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivative comprises one or more monomeric units selected from the group consisting of a monomeric unit of the structural formula 
       
         
           
           
               
               
           
         
       
       a monomeric unit of the structural formula 
       
         
           
           
               
               
           
         
       
       and a monomeric unit of the structural formula 
       
         
           
           
               
               
           
         
       
       wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7  and R 8  are moieties chosen to render the C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivative insoluble in aqueous media. 
     
     
         3 . A composition of  claim 1  wherein the C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivative further comprises one or more linkages chosen from the group consisting of an ester linkage, a urethane linkage, a carbonate linkage and an anhydride linkage. 
     
     
         5 . A composition of  claim 1  wherein the C2-C3 linked polyether of a 1,6:2,3-dianhydrohexopyranose derivative is bioresorbable. 
     
     
         5 . A composition of  claim 1  wherein the polyether of a 1,6:2,3-dianhydrohexopyranose derivative has a weight average molecular weight in the range of about 2 to 350 kDa. 
     
     
         6 . A composition of  claim 5  wherein the polyether of a 1,6:2,3-dianhydrohexopyranose derivative has a weight average molecular weight in the range of about 3 to 150 kDa. 
     
     
         7 . A composition of  claim 1  wherein the polyether of a 1,6:2,3-dianhydrohexopyranose derivative has a polydispersity index less than or equal to 1.5. 
     
     
         8 . A composition of  claim 7  wherein the polyether of a 1,6:2,3-dianhydrohexopyranose derivative has a polydispersity index within the range of about 1.05 to 1.15. 
     
     
         9 . A composition of  claim 1  wherein the polyether of a 1,6:2,3-dianhydrohexopyranose derivative comprises 2.5 to 25 weight percent of the total composition. 
     
     
         10 . A composition of  claim 1  wherein the polyether of a 1,6:2,3-dianhydrohexopyranose derivative comprises 2.5 to 15 weight percent of the total composition. 
     
     
         11 . A composition according to  claim 1  wherein the biocompatible solvent is an aqueous miscible solvent. 
     
     
         12 . A composition according to  claim 11  wherein the aqueous miscible biocompatible solvent is dimethyl sulfoxide. 
     
     
         13 . A composition of  claim 1  further comprising an aqueous media insoluble contrast agent. 
     
     
         14 . A composition of claim  4  wherein the aqueous media insoluble contrast agent is selected from the group consisting of tantalum, tantalum oxide and barium sulfate. 
     
     
         15 . A composition of  claim 1  further comprising a bioactive agent. 
     
     
         16 . A composition of  claim 15 , wherein the bioactive agent is a small molecule pharmaceutical agent. 
     
     
         17 . A composition of  claim 14  wherein the bioactive agent is chemically bonded to the polyether of a 1,6:2,3-dianhydrohexopyranose derivative. 
     
     
         18 . A composition of  claim 1  useful for the embolization of a blood vessel. 
     
     
         19 . A method for embolizing a blood vessel comprising:
 introduction of a sufficient amount of a composition of  claim 1  to a desired site of said blood vessel, wherein upon contact with body fluids the polyether of a 1,6:2,3-dianhydrohexopyranose derivative precipitates to form a solid mass which at least partially occludes the vessel.   
     
     
         20 . A method of  claim 19  wherein the composition of  claim 1  is introduced through an intravascular catheter.

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