Famciclovir and celecoxib combination therapy kit for cognitive dysfunction

Abstract

The present invention relates to methods of treating fibromyalgia, by administering a therapeutically-effective combination of an antiviral component and a COX-2 inhibitor component. The invention is further related to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound famciclovir and a therapeutically-effective amount of the COX-2 inhibitor celecoxib. The invention is also related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of famciclovir and celecoxib.

1 - 29 . (canceled) 
     
     
         30 . A method to treat a subject susceptible to or afflicted with cognitive dysfunction, the method comprising:
 administering to the subject a therapeutically-effective co-acting combination of famciclovir and celecoxib to treat cognitive dysfunction.   
     
     
         31 . The method of  claim 30 , wherein the subject has trouble with verbal recall, basic arithmetic, or concentration. 
     
     
         32 . The method of  claim 30 , wherein each of famciclovir and celecoxib is administered in a dosage amount in combination therapeutically effective to treat cognitive dysfunction. 
     
     
         33 . The method of  claim 30 , wherein the dosage amount of famciclovir is administered in one or more unit doses of at least about 125 mg, and wherein the dosage amount of celecoxib is administered in one or more unit doses of at least about 50 mg. 
     
     
         34 . The method of  claim 30 , wherein the dosage amount of famciclovir is administered in a unit dose range of about 125 mg to about 2000 mg, and wherein the dosage amount of celecoxib is administered in a unit dose range of about 100 mg to about 800 mg. 
     
     
         35 . The method of  claim 30 , wherein the dosage amount of famciclovir is administered in a unit dose range of about 125 mg to about 1500 mg, and wherein the dosage amount of celecoxib is administered in a unit dose range of about 100 mg to about 400 mg. 
     
     
         36 . The method of  claim 30 , wherein the dosage amount of famciclovir is administered in a unit dose range of about 250 mg to about 1000 mg, and wherein the dosage amount of celecoxib is administered in a unit dose range of about 100 mg to about 200 mg. 
     
     
         37 . The method of  claim 30 , wherein the dosage amount of famciclovir is administered in a unit dose of about 625 mg twice a day, and wherein the dosage amount of celecoxib is administered in a unit dose of about 180 mg twice a day. 
     
     
         38 . The method of  claim 30 , wherein the cognitive dysfunction is brain fog, mental fog, or impaired cognition. 
     
     
         39 . A kit presentation for treating cognitive dysfunction, comprising:
 a therapeutically-effective amount of famciclovir,   a therapeutically-effective amount of celecoxib, and   printed directions for administration of famciclovir and celecoxib to obtain a disease-treatment therapeutic outcome,   wherein each of the first and second unit dosage forms is enclosed in one or more containers, and   wherein famciclovir and celecoxib are each present in a dosage amount therapeutically-effective to treat cognitive dysfunction.   
     
     
         40 . The kit presentation of  claim 39 , wherein each of famciclovir and celecoxib is present in a dosage amount therapeutically-effective to treat cognitive dysfunction. 
     
     
         41 . The kit presentation of  claim 39 , wherein famciclovir is present in a unit dosage form to provide a total daily dose in a range of about 500 mg to about 2000 mg, and wherein celecoxib is present in a unit dosage form to provide a total daily dose in a range of about 350 mg to about 400 mg. 
     
     
         42 . The kit presentation of  claim 39 , wherein famciclovir is present in a unit dosage form from about 125 mg to about 500 mg, wherein the total daily dose of famciclovir is in a range of about 500 mg to about 2000 mg. 
     
     
         43 . The kit presentation of  claim 39 , wherein celecoxib is present in a unit dosage form from about 100 mg to about 200 mg, wherein the total daily dose of celecoxib is in a range of about 350 mg to about 400 mg. 
     
     
         44 . The kit presentation of  claim 39 , wherein famciclovir is present in a unit dosage form to provide a total daily dose in a range of about 500 mg to about 1000 mg, and wherein celecoxib is present in a unit dosage form to provide a total daily dose of about 400 mg. 
     
     
         45 . The kit presentation of  claim 39 , further comprising printed directions for administration of kit components to obtain cognitive dysfunction-treatment therapeutic outcome, and wherein the printed directions comprise a cognitive dysfunction-treatment regimen instruction sheet, for treatment of cognitive dysfunction. 
     
     
         46 . The kit presentation of  claim 39 , wherein the regimen instruction sheet further comprises instructions for a two-stage-regimen treatment-period comprising:
 (a) a first stage of an initial seven days of the treatment-period for administering a coacting-combination loading-dose amount of famciclovir in a unit dose in a range of about 500 mg to about 1000 mg, and a coacting-combination loading-dose amount of celecoxib in a unit dose in a range of about 100 mg to about 400 mg; and   (b) a second stage of the remainder of the treatment-period for administering a coacting-combination maintenance-dose amount of famciclovir in a unit dose in a range of about 125 mg to about 1000 mg, and a coacting-combination maintenance-dose amount of celecoxib in a unit dose in a range of about 100 mg to about 200 mg.   
     
     
         47 . The kit presentation of  claim 39 , wherein the printed directions include instructions that each of famciclovir and celecoxib is administered twice-per-day during the first stage and the second stage. 
     
     
         48 . The kit presentation of  claim 39 , wherein famciclovir is present in a total-daily-loading-dose and total-daily-maintenance-dose amount in a range of about 1250 mg to about 1500 mg and wherein celecoxib is present in a total-daily-loading-dose and total-daily-maintenance-dose amount in a range of about 300 mg to about 400 mg. 
     
     
         49 . The kit of  claim 39 , wherein the cognitive dysfunction is brain fog, mental fog, or impaired cognition.