Prohealing piezoelectric coatings

Abstract

Provided herein is a prohealing piezoelectric coating and the method of making and using the same.

What is claimed is: 
     
         1 . A coating on an implantable medical device comprising at least one polarized piezoelectric polymer or material. 
     
     
         2 . The coating of  claim 1 , comprising a polarized piezoelectric polymer. 
     
     
         3 . The coating of  claim 2 , wherein the piezoelectric polymer is selected from poly(vinylidene fluoride) (PVDF), poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), poly(vinylidene fluoride-co-trifluoroethylene) (PVDF-TrFE), poly(vinylidene fluoride-co-tetrafluoroethylene) (PVDF-TFE), or combinations thereof. 
     
     
         4 . The coating of  claim 2 , wherein the piezoelectric polymer is a copolymer comprising units derived from fluoro vinyl monomers. 
     
     
         5 . The coating of  claim 1 , comprising a polarized piezoelectric material. 
     
     
         6 . The coating of  claim 5 , wherein the piezoelectric material comprises a piezoelectric ceramic or a piezoelectric polymer-ceramic composite. 
     
     
         7 . The coating of  claim 6 , wherein the polymer-ceramic composite comprises a multi-layer composite containing a polymer and a piezoelectric ceramic. 
     
     
         8 . The coating of  claim 7 , wherein the polymer is selected from PVDF, PVDF-HFP, PVDF-TrFE, PVDF-TFE, or combinations thereof. 
     
     
         9 . The coating of  claim 6 , wherein the piezoelectric ceramic is selected from lead zirconium titanate (PZT), lead scandium tantalate, barium strontium titanate, lead magnesium niobate, or combinations thereof. 
     
     
         10 . The coating of  claim 6 , wherein the piezoelectric ceramic is selected from Pb(xZr,(1-x)Ti)O 3 , BaTiO 3 , PbZrO 3 , PbTiO 3 , PbNb 2 O 6 , (Pb,Ca)TiO 3 , (Pb,Sm)TiO 3 , Pb(NbO 2 ) 2 /PbTiO 3 , (1-x)Pb(Mg 1/3 Nb 2/3 )O 3 -xPbTiO 3 , (1-x-y)Pb(Zn 1/3 Nb 2/3 )O 3 -xPbTiO 3 -yBaTiO 3 , and (1-x-y)Pb(Zn 1/3 Nb 2/3 )O 3 -xBaTiO 3 -yPbTiO 3 , xPZN-(1-x)PMN, xPMN-(1-x)PZT, PNN-PZ-PT, xPZN-(1-x)PZT, or combinations thereof. 
     
     
         11 . The coating of  claim 1 , wherein the implantable medical device is stent. 
     
     
         12 . The coating of  claim 1 , further comprising at least one bioactive agent. 
     
     
         13 . The coating of  claim 12 , wherein the bioactive agent is selected from paclitaxel, docetaxel, estradiol, 17-beta-estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), biolimus, tacrolimus, dexamethasone, rapamycin, rapamycin derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), γ-hiridun, clobetasol, pimecrolimus, imatinib mesylate, midostaurin, prodrugs thereof, co-drugs thereof, and combinations thereof. 
     
     
         14 . The coating of  claim 1 , further comprising a chemo-attractant for endothelial cells. 
     
     
         15 . The coating of  claim 11 , wherein the chemo-attractant is RGD or cyclic RGD peptide.