Individualized bacterial treatment of pancreatic cancer

Abstract

An individualized bacterial treatment of cancer is provided. The treatment includes a strain of bacteria modified by in-vivo passage through tumor grafts in experimental animals, where the modified strain exhibits enhanced cancer cell-targeting of a specific malignancy arising in a unique individual to the corresponding parent strain of bacteria. The treatment uses this modified strain for the treatment human solid-tumor malignancies by inoculating an individual with a quantity of the strain; and repeating inoculations at periodic intervals where repeated inoculations tend to progressively eliminate the solid tumor malignancy in the individual.

What is claimed is: 
     
         1 . A strain of enhanced cancer cell-targeting bacteria for individualized cancer therapy comprising:
 A modified strain of bacteria, wherein said modified strain is created by at least one in-vivo passage through tumor grafts in experimental animals; and   said modified strain exhibits enhanced cancer cell targeting of a specific malignancy arising in a unique individual compared to a corresponding unmodified strain of bacteria.   
     
     
         2 . The strain of  claim 1  wherein said modified bacteria is a modified  Salmonella typhimurium.    
     
     
         3 . The strain of  claim 1 , wherein said modified strain of bacteria is created by at least one passage through cancer cells in vitro. 
     
     
         4 . The strain of  claim 1 , wherein said specific malignancy is a pancreatic cancer. 
     
     
         5 . The strain of  claim 1 , wherein said specific malignancy is a sarcoma. 
     
     
         6 . The strain of  claim 1 , wherein said specific malignancy is a lung cancer. 
     
     
         7 . The strain of  claim 1 , wherein said specific malignancy is a breast cancer. 
     
     
         8 . The strain of  claim 1 , wherein said specific malignancy is a colon cancer. 
     
     
         9 . The strain of  claim 1 , wherein said specific malignancy is a prostate cancer.