Antiseptic compositions and methods

Abstract

A skin antisepsis composition comprising a vehicle comprising a (C1-4)alcohol and water in a ratio of at least 60:40, a hydroxycarboxylic acid, a cationic film-forming polymer, and at least one antimicrobial agent; and methods of using the composition are provided.

1 . An antiseptic composition for use in disinfecting tissue, wherein the antiseptic composition comprises:
 an antimicrobial agent selected from the group consisting of iodine, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;   a hydroxycarboxylic acid buffer in a molar concentration of at least 0.3 molar; and   water.   
     
     
         2 . The antiseptic composition for use according to  claim 1 , wherein the antiseptic composition further includes one or more nonionic, anionic, or amphoteric surfactants. 
     
     
         3 . The antiseptic composition for use according to  claim 2 , wherein the surfactant is an anionic or amphoteric surfactant. 
     
     
         4 . The antiseptic composition for use according to  claim 3 , wherein the anionic or amphoteric surfactant is selected from the group consisting of sulfonates, sulfates, phosphates, phosphonates, and ammonium sulfonate amphoterics, and mixtures thereof. 
     
     
         5 . The antiseptic composition for use according to  claim 4 , wherein the hydroxycarboxylic acid buffer is present in a molar concentration of at least 0.45 molar. 
     
     
         6 . The antiseptic composition for use according to  claim 1 , wherein the antiseptic composition further includes a film-forming polymer. 
     
     
         7 . The antiseptic composition for use according to  claim 6 , wherein the film-forming polymer is cationic. 
     
     
         8 . The antiseptic composition for use according to  claim 1  wherein the iodophor is povidone-iodine. 
     
     
         9 . The antiseptic composition for use according to  claim 1  wherein the tissue is skin or mucosal tissue. 
     
     
         10 . The antiseptic composition for use according to  claim 9 , wherein the mucosal tissue is nasal or vaginal tissue. 
     
     
         11 . The antiseptic composition for use according to  claim 10 , wherein the mucosal tissue is nasal tissue. 
     
     
         12 . The antiseptic composition for use according to  claim 1 , wherein the antiseptic composition is to be directly applied to the tissue and is to remain on the tissue. 
     
     
         13 . The antiseptic composition for use according to  claim 12 , wherein the antiseptic composition is to be applied prior to surgery, catheterization, or needle puncture. 
     
     
         14 . Use of a hydroxycarboxylic acid buffer for the preparation of an antiseptic composition for disinfecting tissue, wherein the antiseptic composition is as defined in  claim 1 . 
     
     
         15 . The use according to  claim 14 , wherein the tissue is skin or mucosal tissue. 
     
     
         16 . The use according to  claim 15 , wherein the mucosal tissue is nasal or vaginal tissue. 
     
     
         17 . The use according to  claim 16 , wherein the mucosal tissue is nasal tissue. 
     
     
         18 . The use according to  claim 14 , wherein the antiseptic composition is to be directly applied to the tissue and is to remain on the tissue. 
     
     
         19 . The use according to  claim 14 , wherein the antiseptic composition is to be applied prior to surgery, catheterization, or needle puncture.