Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof

Abstract

A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery device. A method for providing prophylaxis against a pulmonary infection in a patient and a method of reducing the loss of antiinfective encapsulated in a lipid-based composition upon nebulization comprising administering an aerosolized pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition is also disclosed.

1 . A method of treatment, comprising: aerosolizing a liquid composition to create aerosolized particles; inhaling the aerosolized particles into a patient's lungs; wherein the liquid composition comprises, a free, unencapsulated ciprofloxacin in an aqueous solution; and a liposome-encapsulated ciprofloxacin wherein the liposomes are comprised of cholesterol and hydrogenated soy phosphatidyl-choline. 
     
     
         2 . The method of  claim 1 , wherein the aerosolized particles have a diameter of about 0.01 microns to about 3 microns. 
     
     
         3 . The method of  claim 1 , wherein the patient is suffering from a lower respiratory tract infection. 
     
     
         4 . The method of  claim 3 , wherein the lower respiratory tract infection is due to P. aeruginosa. 
     
     
         5 . The method of  claim 1 , wherein the patient suffers from cystic fibrosis. 
     
     
         6 . A method of treatment comprising:
 aerosolizing a liquid composition to create aerosolized particles;   inhaling the aerosolized particles into a patient's lungs; wherein the liquid composition comprises:
 a free unencapsulated ciprofloxacin in an aqueous solution; and 
 a liposome-encapsulated ciprofloxacin wherein the liposomes are comprised of cholesterol and hydrogenated soy phosphatidyl-choline, 
 wherein the aerosolized particles have a diameter of about 0.01 microns to about 3 microns.