Rodenticide

Abstract

The present invention relates to rodenticides, methods of killing a rodent comprising administering to said rodent, a lethal dose of an isolated Yersinia murine toxin polypeptide or an isolated antigenic analogue thereof, and methods of manufacturing novel rodenticides.

1 - 68 . (canceled) 
     
     
         69 . A rodenticide comprising a lethal dose of isolated  Yersinia  murine toxin polypeptide, or an isolated antigenic analogue thereof, in a feed;
 wherein the isolated antigenic analogue is a polypeptide capable of killing a rodent in a similar dose dependence as isolated  Yersinia  murine toxin polypeptide and shares more than 60% identity or similarity with SEQ ID NO:2.   
     
     
         70 . The rodenticide of  claim 69  wherein the isolated antigenic analogue shares more than 90% identity or similarity with SEQ ID NO:2. 
     
     
         71 . The rodenticide of  claim 69 , wherein the isolated  Yersinia  murine toxin polypeptide or the isolated antigenic analogue thereof is a recombinant  Yersinia  murine toxin polypeptide or a recombinant antigenic analogue thereof. 
     
     
         72 . A microcapsule comprising a lethal dose of  Yersinia  murine toxin polypeptide, or an isolated antigenic analogue thereof, in a microencapsulation material;
 wherein the isolated antigenic analogue is a polypeptide capable of killing a rodent in a similar dose dependence as isolated  Yersinia  murine toxin polypeptide and shares more than 60% identity or similarity with SEQ ID NO:2.   
     
     
         73 . The microcapsule of  claim 72 , wherein the microencapsulation material is biodegradable. 
     
     
         74 . The microcapsule of  claim 73 , wherein the microencapsulation material enables slow or delayed release of the  Yersinia  murine toxin polypeptide, or the isolated antigenic analogue thereof, in a rodent's body. 
     
     
         75 . The microcapsule of  claim 72  wherein the isolated antigenic analogue shares more than 90% identity or similarity with SEQ ID NO:2. 
     
     
         76 . The microcapsule of  claim 72 , wherein the isolated  Yersinia  murine toxin polypeptide or the isolated antigenic analogue thereof is a recombinant  Yersinia  murine toxin polypeptide or a recombinant antigenic analogue thereof. 
     
     
         77 . The microcapsule of  claim 72 , in a rodent edible feed. 
     
     
         78 . A kit comprising  Yersinia  murine toxin polypeptide, or an isolated antigenic analogue thereof, and a housing container suitable for trapping a rodent or rodents;
 wherein the isolated antigenic analogue is a polypeptide capable of killing a rodent in a similar dose dependence as isolated  Yersinia  murine toxin polypeptide and shares more than 60% identity or similarity with SEQ ID NO:2.   
     
     
         79 . The kit of  claim 78 , wherein the  Yersinia  murine toxin polypeptide, or the isolated antigenic analogue thereof, is in an aerosol. 
     
     
         80 . The kit of  claim 78 , wherein the  Yersinia  murine toxin polypeptide, or the antigenic analogue thereof, is in a form suitable for applying to surfaces with an applicator, further comprising the applicator. 
     
     
         81 . The kit of  claim 78 , wherein the  Yersinia  murine toxin polypeptide, or the isolated antigenic analogue thereof, is in a feed. 
     
     
         82 . The kit of  claim 78  wherein the isolated antigenic analogue shares more than 90% identity or similarity with SEQ ID NO:2. 
     
     
         83 . The kit of  claim 78 , wherein the isolated  Yersinia  murine toxin polypeptide or the isolated antigenic analogue thereof is a recombinant  Yersinia  murine toxin polypeptide or a recombinant antigenic analogue thereof. 
     
     
         84 . The kit of  claim 78 , wherein the  Yersinia  murine toxin polypeptide, or the isolated antigenic analogue thereof, additionally comprises a HIS tag. 
     
     
         85 . The kit of  claim 78 , further comprising one or more protease inhibitors and/or one or more carriers.