Method and system for controlling neural activity in the brain

Abstract

A method and system for controlling neural activity in the brain, including performing a source localization procedure and a neurostimulation procedure, and using the former as a monitor to provide for feedback control of the latter.

1 . A method for controlling neural activity in a brain, comprising:
 performing a source localization procedure for localizing one or more sources of the neural activity;   performing a neurostimulation procedure; and   using said source localization procedure as a monitor to provide for feedback control of said neurostimulation procedure.   
     
     
         2 . The method of  claim 1 , wherein said source localization procedure includes measuring electrical potentials produced by one or more sources of the neural activity and obtaining one or more solutions to an inverse problem for localizing said sources posed by said electrical potentials, wherein said neurostimulation procedure includes injecting one or more stimulating currents into the brain that either alone or in combination are of sufficiently large magnitude to provoke a substantial brain response, for stimulating said one or more sources, wherein said monitor provides for monitoring one or more effects on the brain of said one or more stimulating currents utilizing said one or more solutions, and wherein said feedback control includes modifying at least one of the originating location, magnitude, and timing of at least one of said one or more stimulating currents in response to said monitoring. 
     
     
         3 . The method of  claim 2  for synchronizing the neural activity to said one or more stimulating currents, wherein said monitoring includes observing a phase of electrical activity produced by at least one of said one or more sources, and wherein said feedback control includes modifying said timing so as to shift said phase. 
     
     
         4 . The method of  claim 1 , wherein said feedback control provides for synchronizing the neural activity to said one or more stimulating currents. 
     
     
         5 . A system for controlling neural activity in a brain, comprising:
 a plurality of electrodes and corresponding potential measuring devices configured for measuring electrical potentials produced by one or more sources of the neural activity;   a plurality of electrodes and corresponding current sources configured for injecting one or more stimulating currents into the brain that either alone or in combination are of sufficiently large magnitude to provoke a substantial brain response, for stimulating said one or more sources; and   one or more computers configured for obtaining one or more solutions to an inverse problem for localizing said sources posed by said electrical potentials, monitoring one or more effects on the brain of said one or more stimulating currents utilizing said one or more solutions, and providing for feedback control of the neural activity, said feedback control being applied to said current sources to modify at least one of the originating location, magnitude, and timing of at least one of said one or more stimulating currents in response to said monitoring.   
     
     
         6 . The system of  claim 5 , for synchronizing the neural activity to said one or more stimulating currents, wherein said monitoring includes observing a phase of electrical activity produced by at least one of said one or more sources, and wherein said feedback control includes modifying said timing so as to shift said phase.